St Vincent’s Private Hospital Sydney

LIGO Detector Characterization in the Second and Third Parts of the Fourth Observing Run

Abstract LIGO detector characterization efforts enabled the confident detection of gravitational waves from hundreds of compact binary coalescences during the fourth observing run. Reliable production of high quality detector data and rapid noise mitigation efforts allow the extr...

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

ABSTRACT High‐risk estrogen receptor positive (ER+) early breast cancer (EBC) is managed with endocrine therapies and cyclin‐dependent kinase (CDK) 4/6 inhibitors, although no standard molecular markers clinically identify these tumors. CDK1 lies immediately downstream of CDK4/6...

On-demand therapies–emergency medication or daily routine?

Abstract Fluctuations represent a major therapeutic challenge in Parkinson’s disease (PD) and become increasingly prevalent with disease progression. While oral and device-aided therapies (DAT) improve symptom control, patients continue to experience disabling OFF episodes, in pa...

Finite Element Analysis of Lateral Plate, Intramedullary Nail, and Nail-Plate Combination Techniques in Osteoporotic Distal Femur Fractures

Background: Osteoporotic distal femur fractures are associated with high mechanical complication rates. This study used finite element analysis to compare three fixation methods—lateral plate, intramedullary nail, and nail–plate combination—in an osteoporotic distal femur model....

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

The increasing burden of revision arthroplasty for infection and fracture: perspectives of a tertiary referral centre

Background: In public hospitals the number of complex urgent and semi-urgent revision joint replacements has increased over time, conversely the number of primary joint replacements has decreased. This study aimed to investigate the effect of this change on service delivery of el...

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

BACKGROUND: Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and atte...

Beyond the protocol: navigating ethics and governance in the multicentre implementation trials – the QASC Australasia and T3 Trials

OBJECTIVE: To describe and compare ethics and governance approval timelines for the Quality in Acute Stroke Care (QASC) Australasia Trial (2021-present) and Triage, Treatment, and Transfer of Patients with Stroke in Emergency Departments (T3) Trial (2012-2014), benchmarking again...

Coronal Plane Alignment of the Knee (CPAK) in children and adolescents

Aims: The Coronal Plane Alignment of the Knee classification (CPAK) describes nine knee phenotypes by defining arithmetic hip-knee-ankle angle (aHKA) and joint line obliquity (JLO). In this study, the CPAK classification was used to analyze the development of lower-limb alignment...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...