St Vincents Institute of Medical Research

Recruitment of Aα/Aβ fibers during tonic electrical, optogenetic and combined stimulation in the mouse sciatic nerve

Abstract Background Neuromodulation of peripheral nerves via implanted devices produces relief from chronic pain in some patients, but rarely fully eliminates pain. Electrical stimulation lacks selectivity (e.g., between afferent and efferent fibers) to activate only the target A...

Trajectory of macrotroponin in a community cohort

BACKGROUND: Cardiac troponin I (cTnI) is a biomarker for myocardial injury. However, macrotroponin, a complex of cTnI and endogenous cardiac troponin autoantibodies, may artefactually elevate cTnI levels with potential to mislead clinicians, leading to inappropriate investigation...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Rationale and design of the: breast cancer, fitness and exercise for heart health (BE-FITTER trial)

As breast cancer (BC) survivorship improves, cardiovascular disease (CVD), has become the leading cause of non-cancer death in older survivors. This risk is driven by cardiotoxic treatments, underlying CVD risk factors, and sedentary deconditioning. Despite the established benefi...

A multi-centre study of belatacept and sirolimus for islet transplantation

Abstract Aims/hypothesis Islet transplantation is an appropriate treatment for selected individuals with type 1 diabetes mellitus and hypoglycaemia unawareness. The gold standard of maintenance immunosuppression to prevent allograft rejection is calcineurin inhibitor-based therap...