St. Paul's Hospital

Exploratory investigation of hemodialysis membrane–induced differential DNA methylation in patient blood

Hemodialysis (HD) patients experience chronic inflammation and immune activation driven by continuous blood contact with synthetic dialysis membranes. Increasing evidence suggests that membrane surface chemistry can modulate immune–epigenetic regulatory mechanisms, including DNA...

Contemporary Fibrotic Interstitial Lung Disease Outcomes: A Multicentre National Cohort Study

ABSTRACT Background and Objective This study determined contemporary transplant‐free survival in fibrotic interstitial lung disease (ILD), identified baseline factors associated with death or transplant, and assessed performance of the ILD‐GAP (Gender, Age, Physiology) index in a...

Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow

Abstract Rationale The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assesse...