St. Paul's Hospital Millennium Medical College

Magnitude and determinants of major adverse events and treatment outcomes after surgical repair of ventricular septal defects in children: a 15-year experience

Abstract Ventricular septal defect (VSD) is the most common congenital cardiac anomaly requiring surgical intervention. Although surgical outcomes have improved worldwide, complication rates continue to vary across regions. In Ethiopia, evidence on postoperative outcomes followin...

Marburg virus disease outbreak and response in South Ethiopia Region

Marburg Virus Disease (MVD) is a highly virulent zoonotic infection associated with high case fatality rates and multi-organ dysfunction. Early recognition, timely supportive care, and appropriate clinical management are important in improving outcomes. We describe the clinical p...

Third trimester ultrasound scan for detection of congenital abnormalities and associated factors, at Abebech Gobena MCH hospital, a cross-sectional study

Congenital anomaly is a structural or functional anomaly that occurs during intrauterine life. Growing number of evidences suggest that systematic evaluation of the fetal anatomy during third trimester routine scan increases detection of congenital abnormalities that have been mi...

National trends in heart failure and hyperlipidemia related mortality in the United States, 1999–2024

Cardiovascular disease remains the leading cause of death in the United States, with heart failure (HF) and hyperlipidemia substantially contributing to mortality. This study aimed to examine national trends in HF-related mortality with coexisting hyperlipidemia from 1999 to 2024...

The Role of the MYOC Gene in Primary Open Angle Glaucoma in Ethiopia

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Table S1: MYOC variants reported as causative in individuals of African descent in previous studies...

Concurrent tuberculous and cryptococcal meningitis with hydrocephalus in an HIV- negative patient: a fatal case report

Concurrent central nervous system infections caused by Mycobacterium tuberculosis and Cryptococcus neoformans are exceedingly rare, particularly in HIV-negative (Human Immunodeficiency Virus) immunocompetent individuals, and present significant diagnostic and therapeutic challeng...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Association of Moringa stenopetala based dietary consumption with thyroid function among adults in southern Ethiopia: a multicenter comparative cross-sectional study

Thyroid hormones, including triiodothyronine (T3) and thyroxine (T4), are synthesized by the thyroid gland and play essential roles in regulating metabolism, growth, and neurodevelopment. Prolonged consumption Moringa stenopetala based diet has been suggested as a potential risk...

Whole genome sequencing of multidrug-resistant clinical Klebsiella Isolates from community acquired pneumonia patients at Adama Hospital Medical College, Ethiopia

Klebsiella pneumoniae is a leading Gram-negative pathogen causing severe community-acquired pneumonia (CAP), classically characterized by rapid lung necrosis, cavitary lesions, and production of thick, blood-tinged sputum. CAP is an acute lung infection that develops in a person...

NET-mediated immunothrombosis in ischemic stroke: pathobiology, biomarkers, and therapeutic targeting

Ischemic stroke is increasingly understood not as a purely thromboembolic event but as a thromboinflammatory disease in which innate immune and hemostatic pathways interact. Neutrophil extracellular traps (NETs) have emerged as potentially important mediators and biomarkers withi...

Umbilical port versus epigastric port for gallbladder extraction in laparoscopic cholecystectomy. An updated systematic review and meta-analysis

Laparoscopic cholecystectomy (LC) is the gold standard for gallstone disease, but the optimal extraction port (umbilical vs. epigastric) remains debated. This updated systematic review and meta-analysis aimed to evaluate whether port site selection impacts perioperative and posto...

Factors associated with multidrug-resistant tuberculosis among people living with HIV in Addis Ababa, Ethiopia: a case-control study

Abstract Background Tuberculosis (TB) remains a leading cause of morbidity and mortality globally, particularly in developing countries. Multidrug-resistant TB (MDR-TB), defined as resistance to at least isoniazid and rifampicin, poses a serious public health challenge. People li...

A case of echinococcosis presenting as a slowly growing isolated neck mass in southern Ethiopia: a case report

Echinococcosis, a zoonotic infection caused by Echinococcus granulosus , is a parasitic disease that primarily affects the liver and lungs. However, it can also involve other organs, including the head and neck, although this is extremely rare. We report the case of a 19-year-old...

Bilateral nasolabial cysts: MRI findings in a rare case report

Nasolabial cysts are rare, benign, nonodontogenic, extraosseous maxillofacial lesions, with bilateral involvement being uncommon. A 40-year-old woman presented with long-standing bilateral nasal vestibular swelling. Magnetic resonance imaging (MRI) demonstrated well-defined bilat...