St Olav's University Hospital

Direct and indirect estimation of reference limits for hematologic parameters in adults included in the HUNT study

Reliable reference limits for hematological parameters are essential for clinical interpretation. In this study, we estimated reference limits for hemoglobin, erythrocytes and MCH using direct and indirect methods on data from the Trøndelag Health Study (HUNT). Results from 53,59...

Defining catch-up growth in lung function between adolescence and adulthood: A 25-year population-based study

Background Lung function (LF) development from adolescence to adulthood varies widely. Two related but distinct phenomena are relevant: pronounced growth (large positive change in FEV 1 z-score) and classical catch-up (crossing the lower limit of normal). We aimed to quantify bot...

Device measured physical activity among women with and without adverse pregnancy outcomes: Data from the HUNT study

Background Women with a history of adverse pregnancy outcomes (APOs), including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), small for gestational age (SGA) offspring, preterm birth and placental abruption, are at increased risk of cardiovascula...

Variation in general practitioners’ mental health diagnostic tendencies and subsequent patient care: a Norwegian registry study

Abstract Background General practitioners (GPs) are often the first point of contact for adults presenting with symptoms of depression or anxiety. Practices may vary due to patient and physician tendencies, influencing treatment pathways. This study aimed to quantify variation in...

Obstetric Factors Associated with Pelvic Floor Disorders and Surgery 30 Years After Childbirth: A Prospective Cohort Study

We aimed to compare symptoms of pelvic floor disorders (PFDs) and surgery risk by mode of delivery 30 years after first childbirth and assess symptom changes over time. We also examined associations between PFDs and pelvic floor muscle injuries. Prospective cohort study in 2024 o...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

The Björck classification of the open abdomen revisited: clarifying concepts for modern complex abdomen management

Abstract Introduction The open abdomen (OA) has become an integral component of modern acute care, trauma, and vascular surgery. Since 2009, the Björck classification, amended in 2016, has provided a common language for describing the status and progression of the OA and remains...

Fatigue after ischaemic stroke: A five-year longitudinal study of prevalence and latent trajectory subgroups

Objective To investigate the prevalence and longitudinal course of post-stroke fatigue and identify subgroups with distinct fatigue trajectories up to 5 years post-stroke. Design A prospective, longitudinal, multi-centre cohort study. Setting Hospital stroke units in the Central-...

7 Tesla MRI with Quantitative Susceptibility Mapping: qualitative grading and quantitative focal measurements of the substantia nigra as a potential biomarker for Parkinson’s disease

PURPOSE: Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra (SN). Imaging biomarkers sensitive to nigral pathology are limited. This study evaluated susceptibility changes in the SN using quantitative susceptibility mapping (QSM) and s...

Effects of maternal and paternal smoking on offspring cardiometabolic risk factors in adulthood: a multi-method intergenerational Mendelian randomization study

Abstract Background Parental smoking has been linked to several adverse offspring cardiometabolic outcomes; however, evidence is conflicting regarding the causal and long-term nature of these associations. Methods We investigated the effects of maternal and paternal smoking, capt...