St Michael’s Hospital

Intravascular Lithotripsy in Left Main Stem Percutaneous Coronary Intervention

ABSTRACT Background IVL is increasingly used for coronary calcium modification; however, prospective data for its use in LMS lesions are lacking. Aims To evaluate the feasibility, safety, and mechanical efficacy of intravascular lithotripsy (IVL) for calcium modification in calci...

Adapting and implementing health systems guidelines: learning lessons from countries

Adapting and implementing evidence-based health system guidelines presents numerous challenges, particularly when they are introduced in settings that differ from those in which they were originally developed [ 1 ]. Effective implementation requires careful consideration of local...

Leveraging prompt-driven generative AI for systematic reviews in digital psychiatry: A stage-matched comparative proof-of-concept for healthcare researchers and clinicians

The scale and pace of evidence generation in digital psychiatry increasingly exceed the capacity of traditional systematic literature review (SLR) methods. Large language models (LLMs) are gaining traction in evidence synthesis, yet limited guidance exists for integrating generat...

Team-Based Outpatient Rheumatology Care: A Scoping Review of Terminology, Team Composition, and Impact on Advancing the Quintuple Aim

Objectives Team-based models of rheumatology care, in which rheumatologists and interdisciplinary healthcare professionals (IHPs) collaborate in care delivery, are increasingly recognized to improve outcomes across all domains of the Quintuple Aim (population health, patient expe...

Sex Disparities in Clinical Need, Willingness, and Surgeon Recommendations for Total Knee Arthroplasty

Objectives Sex disparities exist in the receipt of total knee arthroplasty (TKA) for osteoarthritis (OA), with females disproportionately less likely to undergo surgery. Understanding the reasons for this gap is critical for equitable health care delivery. Lower willingness to un...

Unpacking the Comparator: Mapping “Usual Care” in Non-Surgical Knee OA Trials

Objectives “Usual care” is a common comparator in randomized trials (RCTs) evaluating interventions for knee osteoarthritis (OA), but it lacks a standardized definition. This scoping review aimed to systematically map how usual care has been defined and reported in knee OA RCTs,...