St Mary's Hospital

Microbiome-related interventions in benign anorectal disease: a systematic review of clinical evidence and implications for colorectal practice

Abstract Purpose Benign anorectal diseases, including haemorrhoids, anal fissures, anal fistulae, and pruritus ani, are common causes of morbidity with variable treatment outcomes. Emerging evidence suggests that microbial factors may contribute to disease pathophysiology and hea...

Glucocorticoids: an enemy or a friend for the dermatologist? recommendations for proper use and safe discontinuation

Abstract Purpose Glucocorticoids (GCs) are steroid hormones produced by the adrenal cortex with anti-inflammatory and immunoregulating effects, thus essential for the management of numerous inflammatory and autoimmune disorders, including a wide range of dermatological conditions...

Association of non-invasive liver-related scores with cardiovascular disease and a four-domain cardiovascular–renal–hepatic–metabolic phenotype in patients with type 2 diabetes mellitus and MASLD

Abstract Objective Metabolic dysfunction–associated steatotic liver disease (MASLD) is a systemic disorder associated with cardiovascular, renal, and metabolic comorbidities. We evaluated cardiovascular disease (CVD), four-domain cardiovascular–renal–hepatic–metabolic (CRHM) invo...