St. Marianna University School of Medicine

Comparative DIA Proteomics of Neuroblastoma: Laser-Microdissected FFPE Tumors Versus Cell Lines

Formalin-fixed, paraffin-embedded (FFPE) tumor specimens are widely available and represent a valuable resource for retrospective cancer research; however, chemical cross-linking has historically limited their application in proteomic studies. In this study, we developed a proteo...

Genomic Analysis of an IMP-1-Producing Atlantibacter hermannii Bloodstream Isolate Carrying a Transferable blaIMP-1-Harbouring IncHI2/pST1 Plasmid Related to Historical Enterobacterales Plasmids in Japan

Atlantibacter hermannii is an uncommon member of the Enterobacterales rarely associated with human infection, and genomic data on antimicrobial resistance in this species remain limited. Carbapenemase-producing A. hermannii isolates have rarely been described. We characterized an...

Quality of life in hyperkalemia: baseline analysis of a cohort study of management of hyperkalemia in patients with chronic kidney disease or heart failure in Japan

Abstract Background Hyperkalemia is common in chronic kidney disease (CKD) and chronic heart failure (CHF), often leading to treatment dilemmas regarding renin–angiotensin–aldosterone system (RAAS) inhibitors. Although potassium binders and dietary restrictions are central to chr...

Impact of third-party accreditation and general medicine in-training examination participation on residency program popularity: a nationwide matching data analysis in Japan

Abstract Background Third-party accreditation and the visibility of educational outcomes may influence medical students’ choice of training sites; however, national evidence of their effect in Japan is limited. This study examined whether hospital characteristics—especially Japan...

Exploratory analysis of IFN-α-high and CXCL9-high cytokine distributions in systemic lupus erythematosus-associated macrophage activation syndrome

Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory complication of systemic lupus erythematosus (SLE), but its immunopathology remains poorly understood. We investigated cytokine-associated inflammatory heterogeneity in SLE-associated MAS (SLE-MAS). Seru...

Real-world perioperative systemic treatment patterns and postoperative mortality in patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy in Japan: WAKKA-UTUC study

Abstract Background To characterize the longitudinal changes in perioperative systemic treatment patterns and postoperative mortality among Japanese patients with stage II–IV upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy (RNU). Methods This retr...

Divergent proviral load trajectories and clonal dynamics of HTLV-1-infected cells during antirheumatic therapy in rheumatoid arthritis

The optimal management of human T-cell leukemia virus type 1 (HTLV-1) carriers requiring long-term immunomodulatory therapy remains unclear. Patients with rheumatoid arthritis (RA) living with HTLV-1 frequently receive antirheumatic therapy, raising concerns regarding the potenti...

Innovative Method for Evaluating the Optical Properties of Liquid–Liquid Phase Separations Using Laser Scanning Microscopic Spectroscopy

ABSTRACT Liquid–liquid phase separation (LLPS) plays a central role in intracellular compartmentalization and gene regulation. Although optogenetic optoDroplet systems are widely used to study LLPS in living cells, the mechanisms underlying the transition from dynamic liquid‐like...

Neuroprotective Effect of Oral Pemafibrate with Suppression of p-ULK1 Elevation in a Rat Ocular Hypertension-Induced Glaucoma Model

PURPOSE: , its effects on optic nerve axons remain unclear. The purpose of this study was to investigate the effects of oral administration of pemafibrate in a rat model of ocular hypertension glaucoma and to address its molecular mechanisms. METHODS: Laser irradiation was used t...

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (m...

Persistent Hypersensitivity Reactions Associated With Anti‐PEG IgM Antibodies During On‐Demand Therapy With PEGylated Factor VIII in Mild Hemophilia A

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Comparison of response criteria in palliative radiotherapy for bleeding gastric cancer: A secondary analysis of the JROSG 17-3 multicenter prospective observational study

PURPOSE: In radiotherapy for bleeding gastric cancer, no standard response definition exists; studies have used transfusion-only or transfusion-plus-hemoglobin criteria. After inter-facility transfer or during home care-sometimes following palliative radiotherapy-laboratory resul...

Quantitative Assessment of Tongue Atrophy in Amyotrophic Lateral Sclerosis Using Transoral Tongue Ultrasonography ( TOTU ): A Retrospective Single‐Center Study

INTRODUCTION/AIMS: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease accompanied by bulbar dysfunction, in which tongue atrophy contributes to dysarthria and dysphagia. Conventional tongue assessments rely on inspection, palpation, or electrophysiological testing...