St. Luke's Hospital

Endoscopic Versus Microscopic Decompression for Lumbar Spinal Stenosis: A Structured Debate and International Practice Patterns

Endoscopic spine surgery has advanced from a percutaneous niche technique to a mainstream platform for lumbar decompression. This original study examines the relationship between endoscopic and microscopic platforms across 7 contested domains, using an embedded cross-sectional si...

Tarlatamab–Durvalumab Maintenance for Extensive-Stage Small-Cell Lung Cancer

BackgroundPatients with extensive-stage small-cell lung cancer have poor outcomes, with a median overall survival of approximately 12 to 13 months. Tarlatamab (a bispecific T-cell engager targeting delta-like ligand 3 [DLL3] and CD3) was previously shown to improve survival as se...

Bony Anatomy, Soft-Tissue Adaptations and Neuromuscular Risk Factors of Shoulder Injury in Handball Players: A Narrative Review

Handball is a high-intensity contact sport that imposes significant mechanical stress on the shoulder joint through repetitive, high-velocity overhead throwing, predisposing athletes to a wide spectrum of shoulder injuries. This narrative review examines the factors associated wi...

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

Abstract Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I 3 LUNG ( NCT05537922 ) is currently the...

Associations between physical activity levels and self-perceived quality of life and well-being in hemodialysis patients and their informal caregivers: a multicenter cross-sectional study

BACKGROUND: This study aimed to investigate the associations between the physical activity of hemodialysis (HD) patients and their informal caregivers and measures of their well-being and quality of life (QoL). METHODS: This multi-center cross-sectional study included one hundred...

Integrating Instagram into anatomy and histology education: A comprehensive review of current evidence and pedagogical outcomes

Purpose Instagram is a highly popular social media platform, which has been implemented as a teaching modality of several disciplines. We performed a literature review of its use for anatomy and histology teaching, given the lack of reviews with this purpose. Methods We searched...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...