Institution
St. Joseph's Hospital and Medical Center
Recent research
- BiologyOpen access
Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...
- Health & Medicine
Predictive Performance of Screening Methods for Neonatal Opioid Withdrawal Syndrome
BACKGROUND: Routine urine substance screening (USS) in pregnant women for perinatal substance exposure is associated with bias and has limited evidence supporting its use. We evaluated agreement between maternal disclosure, maternal and neonatal USS, and their predictive abilitie...
- BiologyOpen access
Neurodegeneration and inflammation in a novel spinocerebellar ataxia 13 preclinical model
Abstract Neuroinflammation is a critical pathological feature underlying neurodegenerative diseases. Spinocerebellar ataxia 13 (SCA13) is a heterogeneous ataxia with several allelic variations of differing phenotypes. All are neurodegenerative and currently without effective trea...