St. Joseph’s Healthcare Hamilton

Gender disparities in leadership of methodological research in health science

Objectives Gender disparities in methodological studies are largely unexplored. We aimed to examine gender representation between first and last authorship positions in methodological research in health science. Methods We searched for methodological articles as part of a large s...

The RESPOND trial: protocol for a novel phase-based psychotherapy and integrated neurobiological investigation of depression following early life adversity

Exposure to early life adversity (ELA) is one of the most robust predictors of future psychiatric illness. Among individuals assigned female at birth (AFAB), ELA can alter neuroendocrine, epigenetic, and inflammatory processes in ways that increase sensitivity to reproductive hor...

Pharmacological Management of Opioid Use Disorder: A Systematic Review and Network Meta-Analysis: Prise en charge pharmacologique du trouble de l'usage des opiacés : revue systématique et méta-analyse en réseau

Objective To assess the comparative benefits and harms of opioid substitution and antagonist therapies (OSATs) for opioid use disorder (OUD) using a network meta-analysis (NMA) of randomized controlled trials (RCTs). Data Sources Medline, EMBASE, PubMed, PsycINFO, Web of Science,...

Altered Complement and Tubular Mitochondrial Proteins Are Linked to Graft Loss in DSA+ Antibody–Mediated Rejection

Background: Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly associated with AMR. However, 30-60% of DSA + patients do not develop AMR, raising the possibility of local tissue adaptations to...