St. John's University

From Structural Modification to Diverse Pharmacological Activities: Recent Advances and Future Perspectives of Bile Acids

ABSTRACT Bile acids (BAs) are amphiphilic steroid acids that exert a broad range of physiological effects—including the regulation of metabolism, immune responses, and inflammatory processes—through activation of specific receptors such as the farnesoid X receptor (FXR) and the G...

Context “Matters”: Issues of Personal Values, Local Politics, and the Superintendency

Superintendents are asked to make decisions that are in the best interest of K–12 public school children, families, and communities, all while considering the involvement of internal and external influences. This often requires leadership that challenges superintendents’ professi...

Sleep Healthy Using the Internet: A Meta-Analysis of Twenty Years of Research on a Digital Cognitive Behavioral Therapy for Insomnia Program

Abstract Study Objectives To summarize two decades of research on Sleep Healthy Using the Internet (SHUTi), among the most-studied digital Cognitive Behavioral Therapy for Insomnia programs. Methods PubMed, CINAHL, Web of Science, and PsycINFO were comprehensively searched throug...

Magnitude of Survival Benefit Associated With Tyrosine Kinase Inhibitors in Advanced Thyroid Carcinoma: A Systematic Review and Meta-Analysis Incorporating Updated Long-Term Evidence From SELECT (Lenvatinib) and COSMIC-311 (Cabozantinib) Trials

Background: Tyrosine kinase inhibitors (TKIs) have transformed the management of advanced thyroid carcinoma. However, newer agents and updated long-term evidence from pivotal trials have not been comprehensively synthesized. This systematic review and meta-analysis integrates rec...

Evaluating Cell-Free DNA Quantification and Integrity in Breast Cancer Using Fluorometric, Electrophoretic and PCR-Based Platforms

Abstract Background Cell-free DNA (cfDNA) has emerged as a promising biomarker for cancer detection and monitoring. However, different quantification and integrity assessment methods may yield variable results. This study aimed to compare cfDNA concentration and integrity between...