St James's University Hospital

Understanding the Need for Simulation-Based Endourology Training for East, Central, and Southern Africa Urology Residents: A Cross-Sectional Survey Study

Abstract Background Limited access to advanced endourology training in East, Central, and Southern Africa constrains residents’ ability to build confidence and competence in minimally invasive procedures. Simulation based education offers a way to practice core skills outside the...

False Discovery Rate Control for Sparse Correlation Matrix

Abstract Motivation In genomic data analysis, high-dimensional correlation matrices pose challenges in interpreting complex relationships among genomic features, particularly due to overfitting. Traditional approaches generate sparse correlation matrices by setting correlations b...

Core outcome set for quality of life of family caregivers of adults with epilepsy: A Delphi consensus study

OBJECTIVE: Epilepsy significantly affects daily functioning and health-related quality of life (HRQOL) of those living with the condition. Less is known about HRQOL of family caregivers of adults with epilepsy, yet the functioning of patients and caregivers is interlinked, and ca...

Economic and health impact of integrating smoking cessation services into NHS cancer care pathways in England: a modelling study

Background Research has shown that smoking post-diagnosis negatively impacts cancer outcomes. This study aimed to assess the health and cost impacts of introducing smoking cessation services at cancer diagnosis for people who smoke. Methods A cost-effectiveness model was develope...

How to manage: acute-on-chronic liver failure

Acute on chronic liver failure has emerged as a distinct clinical entity over the past few decades. While mortality remains highest for patients who develop liver and multiple non-liver organ failures, earlier recognition of the syndrome, including identification and management o...

44 UK radiotherapy practice in volume delineation–data from the APPROACH trial (ISRCTN:1339049) radiotherapy quality assurance (RTQA) programme benchmark outlining case

Abstract Introduction Interobserver variation in radiotherapy contouring can affect protocol compliance and the robustness of clinical trial outcomes. The APPROACH (Analysis of Proton vs Photon Radiotherapy in Oligodendroglioma and Assessments of Cognitive Health) trial protocol...