Institution
St. James's Hospital
Recent research
- Health & MedicineOpen access
Sepsis in the major burn patient
Abstract Background Sepsis in the context of major burn injury presents a significant challenge to clinicians. It affects a substantial proportion of patients with major burn injury and is the leading cause of death in those that survive to hospital. Due to the complex and profou...
- Health & MedicineOpen access
PET/CT-first staging in anal cancer: reconsidering the role of routine MRI
Multimodal imaging with pelvic MRI and FDG PET/CT is currently recommended for staging anal squamous cell carcinoma (ASCC). However, accumulating data suggest that PET/CT frequently alters staging and radiotherapy planning, raising questions about whether routine MRI is necessary...
- Health & MedicineOpen access
Exploring Long‐Term Outcomes in Sepsis Survivors: A Prospective Cohort Study Across Acute Hospitals
INTRODUCTION: While sepsis survival rates have improved, long-term consequences remain under-recognised and support services limited. Survivors often face persistent physical, cognitive and psychological impairments that diminish their quality of life. AIM: To investigate the lon...
- Society & EconomicsOpen access
Abstract Background The growth of ageing populations is increasing the requirement for professionals trained to care for older adults. Aims To explore factors associated with interest in further training in geriatrics across health and social care professionals. Methods The COST...
- Health & Medicine
Early Satiety in Cancer ‒ the Symptom Experience: Exploratory Cross-Sectional Cohort Study
Background Early satiety (ES) is a common symptom in several conditions, including cancer. Despite presenting at all cancer stages, little is known about how patients describe ES. This study aimed to explore the lived experience of those with ES. Methods A cross-sectional study w...
- Health & MedicineOpen access
Background Fear of cancer recurrence (FCR) represents one of the most frequently reported unmet needs among cancer survivors, with young adults demonstrating heightened susceptibility to its effects. Although a range of specialist-delivered psychological interventions has shown e...
- Health & MedicineOpen access
INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...
- Society & EconomicsOpen access
People experiencing homelessness, or "unhoused people", are eight times more likely to have a diagnosis of epilepsy compared to the general population. However, little is known about how epilepsy is experienced and understood within the context of homelessness. This study used In...
- Health & Medicine
Multidisciplinary Rehabilitation Following Upper Gastrointestinal Cancer Surgery (RESTORE II)
Objective: RESTORE II compared in an RCT the impact of a 12-week multidisciplinary rehabilitation program versus standard care (SC) on cardiorespiratory fitness and physical function in patients postupper gastrointestinal (UGI) oncologic surgery. Summary of Background Data: The v...
- Health & Medicine
INTRODUCTION: Invasive candidiasis remains one of the most challenging infections in the intensive care unit (ICU) because diagnosis is complicated by nonspecific clinical manifestations, frequent colonization, altered host immunity, complex anatomical sources and unstable pharma...
- Health & MedicineOpen access
High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage
High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...
- Physics & Space
Abstract Introduction Interobserver variation in radiotherapy contouring can affect protocol compliance and the robustness of clinical trial outcomes. The APPROACH (Analysis of Proton vs Photon Radiotherapy in Oligodendroglioma and Assessments of Cognitive Health) trial protocol...
- Health & MedicineOpen access
Background: Respiratory syncytial virus (RSV) is a major cause of severe illness in infants and young children. Method: We updated this systematic review to explore the efficacy, effectiveness and safety of authorised maternal RSV prefusion F (RSVpreF) vaccines for infant protect...
- Health & Medicine
Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...
- Health & MedicineOpen access
“Clinical placement logbooks: how do they shape medical student learning behaviours?”
Abstract Background Clinical placement logbooks are widely used to guide learning, document clinical exposure, and support student–tutor feedback. Despite their ubiquity, little is known about how logbooks shape medical students’ learning behaviours, particularly the tension betw...
- Health & MedicineOpen access
Adolescence and young adulthood is characterised by complex developmental and psychosocial changes. The diagnosis of a life-limiting condition adds complexity and stress to this already turbulent period of life. Provision of developmentally appropriate palliative care to this gro...