St. Helena Hospital

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...

A methodological framework for real-world performance studies of clinical variant classification platforms at early organizational stages

Automated platforms that classify sequence variants under the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) framework are increasingly used in rare-disease genomics, yet methodology for characterizing their performance at an earl...

Noodle: Semantic Biomedical Literature Discovery and Navigable Publication Graph

Noodle is a free, public, read-only web application for semantic discovery and navigation of biomedical literature. It integrates publication metadata and source-linked context from PubMed, Europe PMC, and OpenAlex while preserving those services as the authoritative sources. Noo...

Noodle: Semantic Biomedical Literature Discovery and Navigable Publication Graph

Noodle is a free, public, read-only web application for semantic discovery and navigation of biomedical literature. It integrates publication metadata and source-linked context from PubMed, Europe PMC, and OpenAlex while preserving those services as the authoritative sources. Noo...