St George’s University Hospitals NHS Foundation Trust

The next generation of maternal vaccines: scientific advances, regulatory readiness, and strategic planning in Europe

With the recent approval of maternal RSV vaccines and late-phase trials underway for a GBS vaccine, Europe is entering a new era of maternal immunisation. Yet scientific progress is outpacing pregnancy-specific evidence and preparedness for equitable implementation. Pregnant wome...

UK consensus recommendations for onward testing for Lynch syndrome in patients with deficient mismatch repair (dMMR) non-colorectal/non-endometrial cancers

Accepted: 2026) UK consensus recommendations for onward testing for Lynch Syndrome in patients

Association Between Genetic Ancestry and Multiple Sclerosis Severity

OBJECTIVE: The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). METHODS: Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyp...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

High-resolution Manometry Catheter Insertion During Sedated Endoscopy; A Viable Option When Standard Intubation Fails

Background/Aims: : When high-resolution manometry (HRM) intubation is not tolerated or the catheter fails to traverse the lower esophageal sphincter, the test is often abandoned, leaving patients without a diagnosis to guide therapy. Although endoscopic placement of HRM catheters...

Nurse‐Led Telephone Triage Clinic Service for Head and Neck Suspected cancer Referrals: A Prospective Study of 986 Referrals

ABSTRACT Background Head and neck cancer (HNC) referral conversion in the UK is less than 3%. A nurse‐led telephone assessment clinic (TAC) using the HaNC‐RC v.2 triage tool was introduced to identify high‐risk (HR) referrals. Methods Prospective data were collected from all HNC...

Longitudinal health-related quality of life after electrochemotherapy in elderly patients with cutaneous melanoma

The incidence of cutaneous melanoma (CM) is increasing among elderly patients, who often present with advanced disease, including cutaneous metastases. Electrochemotherapy (ECT) is a local ablative treatment that enhances chemotherapy uptake via electric pulses. Management in pat...

The Rare dISease Evaluation (RISE) study: a survey-based investigation of medical student experience and knowledge of rare disease in the UK

Abstract Background Rare diseases are a significant public health concern, with over 6,000 diseases identified with an estimated collective point prevalence of 5.6–6.9%. People living with rare disease face numerous challenges within healthcare including prolonged time to diagnos...

Clinical outcomes of bleomycin electrosclerotherapy (BEST) for the treatment of slow-flow vascular malformations (SFVMs): a UK single-centre experience

BACKGROUND: Bleomycin Electrosclerotherapy (BEST) is an emerging treatment for slow-flow vascular malformations (SFVMs), utilising electroporation to enhance intralesional bleomycin uptake. This study evaluates the safety and clinical outcomes of BEST in reducing symptom severity...

Long-term outcomes of first episode affective psychosis in postpartum women

BACKGROUND: Outcomes of first episode postpartum psychosis and their distinction from outcomes of non-postpartum psychosis are poorly characterised. AIMS: To characterise the disease course and outcomes of first episode postpartum psychosis, compared with first episode non-postpa...