St George's Hospital

Intravascular Lithotripsy in Left Main Stem Percutaneous Coronary Intervention

ABSTRACT Background IVL is increasingly used for coronary calcium modification; however, prospective data for its use in LMS lesions are lacking. Aims To evaluate the feasibility, safety, and mechanical efficacy of intravascular lithotripsy (IVL) for calcium modification in calci...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

The Co-Occurrence of Postural Orthostatic Tachycardia and Functional Neurological Disorder: A Meta-Analysis and Narrative Synthesis

Background: Functional Neurological Disorder (FND) and Postural Orthostatic Tachycardia Syndrome (POTS) are both complex, often debilitating conditions that frequently affect young women and involve high symptom burdens and psychiatric comorbidity. Although clinical overlap betwe...