St George Hospital

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

ABSTRACT High‐risk estrogen receptor positive (ER+) early breast cancer (EBC) is managed with endocrine therapies and cyclin‐dependent kinase (CDK) 4/6 inhibitors, although no standard molecular markers clinically identify these tumors. CDK1 lies immediately downstream of CDK4/6...

The impact of changing Coronal Plane Alignment of the Knee classification on early functional outcomes after primary robotic-assisted total knee arthroplasty

Aims We aimed to determine the impact of changing a patient’s Coronal Plane Alignment of the Knee (CPAK) phenotype on early functional outcomes after robotic-assisted total knee arthroplasty (RA-TKA). Methods We conducted a retrospective multicentre cohort study of 297 patients u...

Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial

Fluid resuscitation in early septic shock has a narrow therapeutic index. Signals of fluid intolerance are frequently present during early resuscitation, yet current resuscitation strategies do not incorporate them to guide when to limit fluid administration. We evaluated whether...

Extracellular vesicles in breast cancer metastasis: functional insights and advances in single-EV analysis

Abstract Breast cancer (BC) metastasis remains a leading cause of mortality despite significant advances in screening and diagnosis. Extracellular vesicles (EVs), secreted by all living cells, carry biologically active cargo such as RNAs and proteins, playing a crucial role in ce...

Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis

Objective To quantify exercise dose-response relationships and estimate the optimal dose in adults with chronic low back pain disorders (CLBDs). Design Systematic review with random-effects model-based (non-linear) dose-response network meta-analysis. Risk of bias was assessed wi...

A Silent Killer in an Unlikely Place: Necrotizing Fasciitis of the Breast

Background: Primary necrotizing fasciitis (NF) of the breast is a rare, life-threatening soft tissue infection that is frequently misdiagnosed due to its non-specific early presentation and uncommon anatomical location. Objective: We report a case of primary NF of the breast to h...

DOES ROBOTIC-ASSISTED SURGERY OR FUNCTIONAL ALIGNMENT IMPROVE INTRAOPERATIVE BALANCE IN TOTAL KNEE ARTHROPLASTY? A SECONDARY ANALYSIS OF THE RASKAL TRIAL

Abstract Background This study assessed rates of imbalance in total knee arthroplasty (TKA) and its effect on patient-reported outcome measures (PROMs), comparing robotic-assisted surgery (RAS) versus computer-assisted surgery (CAS), and functional alignment (FA) versus mechanica...

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants

Importance The optimal initial fraction of inspired oxygen (F io 2 ) for delivery room resuscitation of neonates born at 32 to 35 weeks’ gestation is unknown. Objective To compare outcomes for neonates born at 32 to 35 weeks’ gestation when initiating resuscitation with F io 2 0....

A cost-effectiveness analysis of selective decontamination of the digestive tract in mechanically ventilated patients in the intensive care unit

Objective To evaluate the 24-months cost-effectiveness of selective decontamination of the digestive tract (SDD) versus standard care in mechanically ventilated Intensive Care Unit (ICU) patients. Design Within‑trial cost‑effectiveness analysis using linked administrative healthc...

The Association of Umbilical Cord Blood Neurofilament Light With Nonreassuring Fetal Status: A Prospective Observational Study

( Int J Gynaecol Obstet . 2026 Mar;172(3):1491–1500. doi:10.1002/ijgo.70421) A prospective observational study explored whether neurofilament light (NfL), a marker of neuronal injury, can be reliably measured in umbilical cord blood and whether it is associated with nonreassuring...

Coronal Plane Alignment of the Knee (CPAK) in children and adolescents

Aims: The Coronal Plane Alignment of the Knee classification (CPAK) describes nine knee phenotypes by defining arithmetic hip-knee-ankle angle (aHKA) and joint line obliquity (JLO). In this study, the CPAK classification was used to analyze the development of lower-limb alignment...

Pembrolizumab and Denosumab in Clear-Cell Renal-Cell Carcinoma.

BACKGROUND: Anti-PD1 immune checkpoint inhibitors (ICI) are effective in clear-cell renal-cell carcinoma (ccRCC). Preliminary data suggest inhibition of Receptor Activator of Nuclear Factor-κB Ligand (RANKL) signaling may potentiate ICI efficacy. We evaluated the activity and saf...