St. Anna Hospital

A survey on the institutional practices of the use of isavuconazole in onco-hematological children, on behalf of the Infectious Working Group of AIEOP

Isavuconazole is a broad-spectrum antifungal agent approved for the treatment of invasive fungal infections (IFIs) in adults and, recently, in pediatric patients aged 1 year and older. Use in the pediatric setting remains limited, but available data indicate generally favorable s...

Chemical Synthesis of Acybolins Reveals Their Antiproliferative Activity

Abstract An efficient synthetic access to the acybolin class of inducible secondary metabolites is being reported. The approach developed features coupling between the antibiotic (−)-bactobolin A and various acybolin side chains without the need for protecting groups. The biologi...

Low Postoperative Cholesterol Level Is Associated with Adverse Outcomes After Coronary Artery Bypass Grafting

Low cholesterol levels have been linked to severe illness, including sepsis. This study evaluated whether early postoperative cholesterol levels are associated with adverse outcomes in patients after elective Coronary Artery Bypass Grafting with extracorporeal circulation. This r...

Exploring patients’ experiences and perceptions of manipulation under anesthesia for stiffness after total knee arthroplasty: a qualitative study

Purpose To gain in-depth insight into the experiences and perceptions of patients requiring manipulation under anesthesia (MUA) for persistent stiffness after total knee arthroplasty (TKA).Material and methods A pragmatic qualitative study using the interpretive description appro...