Ss. Cyril and Methodius University in Skopje

Raman Spectroscopic Characterization of the Benzene:Acetonitrile (3:1) Cocrystal Relevant to Titan, Saturn’s Moon

Abstract Titan, Saturn’s largest moon, hosts active organic chemistry and surface environments where small molecules are expected to crystallize as molecular minerals. Benzene and acetonitrile, both predicted to be present on Titan, were shown to form a thermodynamically stable b...

Lowering Coordination Symmetry as a Strategy for Tuning Slow Magnetic Relaxation in Quasi-Isotropic Mn(II) Systems

Abstract Two pentacoordinate Mn(II) complexes containing tridentate 2.2′-[oxybis(methylene)] bis(1H-1,3-benzimidazole) (OMeBB) ligand and pseudohalide coligands, [Mn(OMeBB)(NCS)2] (1) and [Mn(OMeBB)(NCO)2] (2), exhibit a very rare {MnIIN4O} coordination mode involving semicoordin...

Structural validity and measurement invariance of the WHO-5 Well-Being Index among young adolescents in a family-focused prevention context in Southeastern Europe

Abstract Background The World Health Organization Five Well-Being Index (WHO-5) is a widely used, open-access measure of subjective well-being. However, evidence on its psychometric properties among young adolescents participating in preventive interventions in low- and middle-in...

Modulating splicing in 5ʹ untranslated regions to treat rare haploinsufficient disease

Abstract Background Rare genetic disorders collectively impact over 300 million people worldwide, yet around 95% have no specific treatments. For the many rare disorders caused by haploinsufficiency, effective therapies need to upregulate protein expression. However, therapeutic...

Design Analysis of Line Start Synchronous Motor with Salient Poles for Efficiency Improvement

Line-start synchronous motors (LSSMs) have emerged as a promising alternative to induction motors in response to increasingly stringent energy-efficiency requirements. However, the salient-pole permanent-magnet rotor topology has been comparatively less studied than other LSSM ro...

Contact Sensitization and Polysensitization in a Tertiary Referral Cohort of Children With Moderate‐To‐Severe Atopic Dermatitis

BACKGROUND: Children with atopic dermatitis (AD) demonstrate increased susceptibility to contact sensitization (CS) due to epidermal barrier dysfunction and chronic cutaneous inflammation. However, the frequency and patterns of contact sensitization in paediatric AD remain incomp...

Structural Analysis of Barriers to Waste-to-Energy Cogeneration Plant Implementation in Skopje Using Interpretive Structural Modelling (ISM) and Cross-Impact Matrix Multiplication Applied to Classification (MICMAC) Framework

The city of Skopje faces persistent inefficiencies in waste management, characterised by rising waste generation and limited progress in sustainable treatment solutions. This paper addresses the need for a structured approach to identify barriers to implementing Waste-to-Energy (...

Towards resilient forest establishment in Europe: functional traits, genetic diversity and multifunctional design

Abstract Forest restoration and afforestation across Europe are accelerating, yet the decision-making processes governing forest establishment remain unevenly examined, especially from a biodiversity perspective. Considering this and the global environmental changes of climate sh...

Treatment discontinuation after complete response to BRAF/MEK inhibition in metastatic melanoma: long-term clinical outcomes from a single institution

The optimal duration of BRAF/MEK inhibitor therapy in patients with metastatic melanoma who achieve complete response remains uncertain. Although targeted therapy is commonly continued until disease progression or unacceptable toxicity, prolonged treatment may be associated with...

Dysregulated adult hippocampal neurogenesis in major depressive disorders

Major depressive disorder (MDD) is associated with reduced hippocampal volume, altered connectivity and negative memory bias, suggesting disrupted hippocampal plasticity. Dysregulated adult hippocampal neurogenesis is a potential contributor, but its relevance in humans and role...

Stress Management as a Systemic Process of Psychological Regulation

The aim of this study was to develop an integrated theoretical model of stress management based on a multi-level analysis of the mechanisms of psychological regulation under stress conditions. The research employed a systemic approach and utilised methods of scientific literature...

Towards Personalized Medicine in Chronic Kidney Disease: A Roadmap for the future of Early Detection, Diagnosis, and Management: A Consensus Roadmap from the EUTox, PerMedik and KidneyHealth networks

Chronic kidney disease (CKD) affects more than 800 million individuals worldwide and represents one of the fastest‑growing causes of morbidity and mortality. Despite major therapeutic advances, CKD is frequently detected only after substantial and irreversible loss of kidney func...