Sri Ramakrishna Institute of Paramedical Sciences

A Comprehensive Review on the Antimicrobial Culture Susceptibility Patterns and Intravenous-to-Oral Conversion of Antibiotics

Abstract Antimicrobial resistance is a major challenge in managing bacterial infections, emphasizing appropriate antibiotic selection, culture-directed therapy, and antimicrobial stewardship. This review summarizes antimicrobial culture and susceptibility patterns and examines th...

From Firewood To Photovoltaics: Household Energy Transition And Environmental Change In Pathanamthitta District, Kerala

Abstract Energy transitions have historically shaped the relationship between society, economy, technology, and the environment. In Kerala, household energy consumption has undergone a substantial transformation during the last seven decades, moving from dependence on traditional...

From Firewood To Photovoltaics: Household Energy Transition And Environmental Change In Pathanamthitta District, Kerala

Abstract Energy transitions have historically shaped the relationship between society, economy, technology, and the environment. In Kerala, household energy consumption has undergone a substantial transformation during the last seven decades, moving from dependence on traditional...

Gut dysbiosis in PMOS: link to MASLD and role of synbiotics

AbstractPolyendocrine metabolic ovarian syndrome (PMOS), previously termed Polycysticovary syndrome (PCOS), is a multifactorial endocrine and metabolic disordercharacterized by hyperandrogenism, ovulatory dysfunction, insulin resistance, obesity,chronic low-grade inflammation, an...

Closed-loop predictive resonance control through adaptive stiffness–damping co-regulation for continuous piezoelectric energy harvesting

Piezoelectric energy harvesting offers a sustainable solution for powering autonomous electronic devices, but conventional harvesters suffer from resonance mismatch under varying vibration frequencies. In this research, a Closed-Loop Predictive Resonance Control with Adaptive Sti...

In Silico Design and Computational Evaluation of Pyrazolo Cinnoline Analogs as Potential Phosphodiesterase Inhibitors for Breast Cancer

AbstractBreast cancer remains a major global health challenge due to its complex molecularmechanisms, therapeutic resistance, and limitations of existing treatments. Phosphodiesterase10A (PDE10A), a dual-specificity phosphodiesterase regulating intracellular cAMP and cGMPlevels,...

Exploring the Quantum Chemical and Inhibitory Footprint of Coumarin Derivatives Against α-Amylase: A Unified in Silico and ADMET Profiling Study

Abstract Diabetes mellitus is a prevalent metabolic disease associated with persistent elevation of blood glucose and represents a significant challenge in the search for effective and well-tolerated therapeutic agents. Targeting α-amylase, a key enzyme involved in the hydrolysis...

Exploring the Quantum Chemical and Inhibitory Footprint of Coumarin Derivatives Against α-Amylase: A Unified in Silico and ADMET Profiling Study

Abstract Diabetes mellitus is a prevalent metabolic disease associated with persistent elevation of blood glucose and represents a significant challenge in the search for effective and well-tolerated therapeutic agents. Targeting α-amylase, a key enzyme involved in the hydrolysis...

Structure-guided multiscale evaluation of 5-nitroisatin mannich bases targeting pantothenate synthetase: DFT, ADMET, molecular docking, molecular dynamics and In Vitro antitubercular screening

AbstractAn integrated drug-discovery strategy was employed to design, synthesize, and evaluate aseries of isatinmannich bases as potential antitubercular agents, combining computationalapproaches with experimental biological screening. Structurally diverse isatinmannichderivative...