Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi

Preoperative Upper Gastrointestinal Endoscopy in Metabolic and Bariatric Surgery: A Narrative Review of Current Evidence and Clinical Recommendations

Metabolic and bariatric surgery (MBS) represents the most effective therapeutic approach for achieving substantial and sustained weight loss and improving obesity-related comorbidities. However, the role of routine preoperative esophagogastroduodenoscopy (EGD) remains controversi...

Diagnostic and Management Challenges in Mixed-Source MDR Sepsis in a Kidney Transplant Recipient with an Infected Sacral Pressure Ulcer Treated with VAC Therapy: A Case Report

Background: Kidney transplant recipients are particularly vulnerable to severe infections because of chronic immunosuppression, impaired wound healing, repeated healthcare exposure, and the potential nephrotoxicity of antimicrobial therapy. We report a complex case of multidrug-r...

Advanced Endometrial Cancer Mimicking Pelvic Inflammatory Disease in a Postmenopausal Woman—A Case Report

Background: Endometrial cancer is the most common gynecological malignancy in high-income countries, with recurrence occurring in approximately 8.3% of endometrioid endometrial carcinoma cases. Recurrence in elderly patients is associated with significantly worse outcomes, compou...

Comorbidity Count Versus the Charlson Comorbidity Index in Predicting Hospital Stay After Hip Fracture in Older Adults: A Retrospective Cohort Study

Background and Objectives: Hip fracture in older adults is associated with high morbidity, and length of hospital stay is the simplest summary of the acute admission. We aimed to identify the clinical factors associated with prolonged hospital stay in older adults admitted with a...

The Thoracic Footprint of Hepatocellular Carcinoma: A Mechanism-Based Imaging Narrative Review

A thoracic finding in a patient with hepatocellular carcinoma (HCC) may represent metastatic disease, vascular extension, treatment-related injury, or a complication of cirrhosis, and each carries different implications for staging and care. The mechanism behind the finding there...

Recurrence of Benign Vocal Fold Lesions: Risk Factors and an Exploratory Comparison of Cold-Instrument and CO2 Laser Surgery in a Retrospective Cohort

Background and Objectives: Benign vocal fold lesions (BVFLs) are common causes of persistent dysphonia, but recurrence estimates are influenced by lesion type, outcome definition, and follow-up. We evaluated recurrence after documented lesion resolution and explored clinical fact...

Revisiting gallbladder stones structure through integrated multiscale physicochemical characterization

Gallstones are complex biominerals formed through physicochemical, metabolic, and microbial processes. In this study, gallstones were comprehensively characterized, revealing a complex elemental profile comprising C, N, O, Mg, Al, Si, P, S, Ca, Cu, Mn, Fe, Co, Zn, and Cd. The cha...

The Bile Acid–Diet–Microbiome Axis in Clostridioides difficile Infection

Clostridioides difficile infection (CDI) remains a major cause of antibiotic-associated diarrhea, with recurrence largely driven by disruption of the gut microbiota and impaired colonization resistance. Bile acids have emerged as key mediators in this process, as primary conjugat...

Vitamin D Supplementation in Infertile Men: Beyond Pooled Effects—A Critical Meta-Analysis of Heterogeneous Clinical Responses

Introduction: Male infertility is a complex global health challenge, with emerging evidence suggesting that vitamin D plays a pivotal role in testicular function and spermatogenesis. This systematic review and meta-analysis aimed to evaluate the impact of vitamin D supplementatio...

Anterior Cruciate Ligament Reconstruction: Clinical Outcomes and Biomechanical Considerations of Graft Selection—A Narrative Review

Anterior cruciate ligament (ACL) reconstruction represents the current gold standard for restoring knee stability following ligament rupture, particularly in young and physically active individuals. The aim of this narrative review is to provide an updated overview of the biomech...

Maternal Cardiovascular Phenotype in Fetal Growth Restriction with or Without Pre-Eclampsia: Insights from Echocardiography and Clinical Implications

Fetal growth restriction (FGR) has traditionally been attributed to placental insufficiency. However, accumulating evidence suggests that maternal cardiovascular maladaptation contributes to disease expression, clinical heterogeneity, and long-term maternal cardiovascular risk. T...