Spencer Foundation

President’s Column: Make the Most of ATCE 2026: A Strategic Investment in Your Career and Organization

_ October is an exciting time for SPE members around the world because it means the Annual Technical Conference and Exhibition (ATCE) is nearly here. This year, ATCE will take place 21–23 October, at the George R. Brown Convention Center in Houston. Whether you are an experienced...

Meta-regression model choice and the interpretation of trial-level surrogacy

The use of surrogate endpoints can improve feasibility of clinical trials. The results of trial-level analyses are a key factor affecting regulatory policy regarding the uptake of a surrogate endpoint. Trial-level analyses aim to quantify the strength of association between treat...

Lenacapavir allosterically remodels the HIV-1 capsid

Lenacapavir (LEN) is a highly potent, long-acting HIV-1 capsid inhibitor that holds exceptional promise for pre-exposure prophylaxis. LEN causes the mature viral capsid to rupture and lose integrity, but the underlying mechanism has been unclear. Here, we show that LEN is an allo...

Statistical methods, outcome structures, and research designs in hybrid type II effectiveness-implementation studies: protocol for a scoping review

<ns5:p>Background Hybrid type II effectiveness-implementation studies evaluate health intervention and implementation strategy effectiveness simultaneously. While the emphasis on each “side” varies within hybrid type II studies, the focus of this review is those that attempt a mo...