Spaulding Rehabilitation Hospital

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Needle-Related Procedural Pain: An Integrated Nervous-System Framework from Tissue Mechanics to Central Processing—A Systematic Review

Background/Objectives: Needle procedures cause acute pain through mechanical, chemical, sensory, and affective processes. We synthesized human and animal evidence and developed a framework spanning peripheral nociception, spinal/trigeminal modulation, central processing, and clin...

Lifetime History of Concussion in Children With Attention-Deficit/Hyperactivity Disorder

Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for concussion. Sociodemographic differences in health literacy and access to health care might contribute to race-associated differences in concussion among children. This study i...

Measuring the Acute Effects of Concussion on the Sway Medical System Sports+ Test Battery

OBJECTIVE: To document the acute effects of sports-related concussion in student athletes on tests of balance and cognitive functioning, as measured by the Sway Medical System Sports+ test battery, compared with their baseline preinjury test scores. DESIGN: Retrospective observat...

Functional Brain Network Alterations Linked to Cancer-Related Cognitive Impairment in Breast Cancer Patients

Abstract Background Life expectancy for cancer patients has improved due to new therapies, but many survivors experience long-lasting side effects, including cancer-related cognitive impairment (CRCI). CRCI symptoms—such as difficulties with attention, memory, processing speed, f...

Elevated translocator protein in skull bone marrow is linked to human chronic pain

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a pu...

Beyond Survival: Outpatient Treatment for Functional Recovery After Brain Injury

Abstract Acquired brain injuries (ABIs), including hypoxic-ischemic and traumatic injuries, are leading causes of long-term disability in children. While acute treatment has advanced, many survivors face persistent cognitive, emotional, and physical challenges that require coordi...

Resident-led Board Review-focused Didactics Improve Physiatry Self-assessment Examination Scores

We implemented an educational intervention centered on resident-led, board review-focused didactics to improve Self-Assessment Exam for Residents (SAE-R) scores at our institution, carried out over two academic years (2024-2025 and 2025-2026). As a result, mean percentile scores...

Safety and Efficacy of Colchicine for the Treatment of Pericarditis in Patients with Chronic Kidney Disease

This retrospective multicenter cohort study compared the safety and efficacy of low- versus high-dose colchicine in adult patients with chronic kidney disease (CKD) treated for pericarditis between August 2015 and August 2024. CKD was identified using ICD codes and confirmed by a...