Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition

Early‐Life Betaine Supplementation Drives Sex‐Specific Metabolic Programming in Rats, Affecting FGF21 Signaling and Energy Balance

ABSTRACT We aimed to evaluate the effects of maternal diet and betaine supplementation during the suckling period on Fgf21 expression and metabolic pathways related to FGF21 signaling and metabolic programming. Offspring of Wistar rats fed either a chow diet (CD) or a Western die...

Influence of Particle Size Fractionation via Pulse Spray Drying on the Physicochemical and Functional Properties of Fruit Smoothie Powders

Fractionation of powders by Pulse Spray Drying (PSD) may improve drying behaviour in fruit smoothies prepared with apple, orange, banana, and whey protein. The objective of this study was to determine whether cyclone-based fractionation via PSD yields smoothie powder fractions wi...

Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trial

Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-term, multicomponent weight-loss programmes remains unclear. This study evaluated the impact of an i...

Comparative analysis of maternal diet and its individual compounds in pregnancies with and without preeclampsia

Maternal diet during pregnancy may influence maternofoetal outcomes, including the occurrence of preeclampsia. The objective was to assess the association of maternal adherence to a Mediterranean diet pattern with preeclampsia, and the correlation with surrogate makers of the dis...

Mediterranean lifestyle and risk of recurrent cardiovascular events: a prospective study from the UK biobank

Abstract Background The Mediterranean Lifestyle Index (MEDLIFE) evaluates adherence to traditional Mediterranean living, encompassing diet, physical activity, rest and conviviality. Although it has been linked to reduced risk of cardiovascular disease (CVD), diabetes, and other c...

Urinary Hypaphorine as a Candidate Marker of FFQ-Derived Legume Intake Within the EAT-Lancet Framework in Free-Living Adults

Dietary assessment is affected by recall, reporting, portion-size error, and food-composition inconsistencies. Hypaphorine, a tryptophan-derived betaine alkaloid found in pulses and other foods, has been proposed as a marker of legume exposure, but its performance in free-living...

Comparative analysis of blood inflammatory profile and intestinal microbiota in late-fetal growth restriction vs. normal pregnancy

To determine the association of blood inflammatory biomarkers and intestinal microbiota composition in women with late-onset fetal growth restriction. Fetal growth restriction (FGR) is a pathological condition in which fetus fails to achieve its genetically determined growth pote...

Mental Health and Psychological Constructs Related to Performance in Professional, Semi-Professional, and Competitive Adolescent Women’s Soccer Players: A Scoping Review

Background: Mental health has become a fundamental component of the sports world. Although previous studies have addressed psychological aspects of women’s soccer, no comprehensive review has mapped both mental health symptoms and adaptive psychological resources and psychophysio...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Eating Behavior Latent Profiles and Their Associations With Body Composition in Early Childhood: The CORALS Cohort

ABSTRACT Objective This study aimed to identify sex‐specific eating behavior profiles and assess the associations between eating behaviors subscales and profiles and body composition indices in Spanish preschoolers from the CORALS cohort. Methods We conducted a cross‐sectional an...

Sex-specific cognitive and metabolic effects of lifelong caloric restriction and sodium butyrate administration in aging rats

Aging is associated with progressive metabolic dysfunction and cognitive decline, which is often accompanied by hippocampal dysfunction and sex-specific vulnerabilities. Caloric restriction (CR) and sodium butyrate (NaBu), a short-chain fatty acid that acts as a histone deacetyla...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...