Southern California Clinical and Translational Science Institute

Leveraging Long-Read Sequencing to Bridge the Diagnostic and Equity Gaps in Differences of Sex Development (DSD)

Congenital Adrenal Hyperplasia (CAH) can result from variants in several genes but is most frequently caused by deletions and gene conversions in the segmentally duplicated RCCX module, which contains the CYP21A2 gene and its pseudogene. Current genetic tests vary greatly by labo...

ERGA-BGE Reference Genome: Corema album ((L.) D. Don, 1830) - the Portuguese crowberry, endemic to the Iberian Peninsula.

Corema album is a perennial, dioecious shrub endemic to the Atlantic coast of the Iberian Peninsula and the Azores. It inhabits coastal dune ecosystems from Galicia to the Strait of Gibraltar, where it plays an important ecological role. The goal of this study was to assemble and...

Virtual parenting intervention to promote positive parenting and prevent child anxiety and depression symptoms among filipino americanfamilies: protocol for a randomized controlled trial

Filipino youth in the U.S. experience higher rates of depression, suicidal ideation, anxiety, and substance use when compared to other Asian subgroups and non-Hispanic whites, yet are less likely to seek help or receive preventive care. Evidence-based parenting interventions have...

Adapting and implementing “Compassionatomy”: a compassion-cultivating approach to humanistic anatomy training for medical students

Abstract Background Humanistic practices offer many benefits in medical education. Compassionatomy, developed at University of California San Diego, incorporates humanistic compassion-cultivating practices into anatomy labs and was found to increase identification with body donor...

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis

Metastatic dissemination is the principal cause of death in pancreatic ductal adenocarcinoma (PDAC), yet the molecular determinants that enable this process remain poorly understood. Here, we identify the axon guidance receptor UNC5B as a central regulator of PDAC metastasis. Usi...