Southampton General Hospital

Anti-fibrillarin Positive Systemic Sclerosis Presenting With Myositis and Perimyocarditis

A 45-year-old man with no significant past medical history presented with six months of progressive proximal muscle weakness, inflammatory arthralgia, and functional decline, on a background of two years of progressive depigmented pruritic skin lesions.Examination demonstrated wi...

Deletion or immunotherapeutic blockade of FcγRIIb (CD32b) impairs α-Syn propagation in vivo

Abstract Parkinson’s disease (PD), the most prevalent neurodegenerative movement disorder, is characterised by widespread alpha-synuclein (α-Syn) pathology in the brain and the progressive degeneration of nigrostriatal dopaminergic neurons. Experimental and clinicopathological da...

The Activity of Antimicrobial Peptides (AMPs) Identified Via an Integrated in Silico and Pilot in Vitro Screening Approach Towards ESKAPE Pathogens

Abstract Antimicrobial resistance (AMR), driven largely by ESKAPE(E) pathogens, represents a critical global health challenge. The increasing prevalence of multidrug-resistant (MDR) bacteria and the declining effectiveness of conventional antibiotics have created an urgent need f...