South Australian Health and Medical Research Institute

Kidney Donation After Circulatory Death Is Associated With Sustained Graft Function, Comparable Graft, and Patient Survival.

Background: Kidney transplantation is the preferred treatment for kidney failure, offering various benefits, yet donor supply remains limited worldwide, including in Australia and New Zealand. We examined long-term outcomes of kidney transplant recipients from donation after circ...

Quantitative single cell analysis of gold nanoparticle association across a mouse triple-negative breast cancer cell line and blood immune cell populations

In biomedical research, understanding the heterogeneity in nanoparticle association among different cell populations is crucial for translating to efficacy and immune identification. Using time-of-flight mass cytometry (CyTOF), we quantitatively assessed the association and distr...

Diet Quality and Weight Gain Among Women in the Aboriginal Family Birthing Program in South Australia

Background: This study assessed diet quality and the association between engagement with nutrition support bundles and weight gain among pregnant women having Aboriginal and Torres Strait Islander babies who participated in the Aboriginal Family and Baby Bundles implementation pr...

International Travel for Organ Transplantation: 2024 Multinational Survey of Routes, Organs, and Donor Types

BACKGROUND: International travel for organ transplantation (ITOT) reportedly affects ≥2% of global solid organ transplant activity, yet detailed information about ITOT participants, organ types, travel configurations, and clinical settings remains scarce. Previous research has fo...

Online peer support in long-term physical health conditions: a feasibility randomised controlled trial

Thirty percent of the UK population live with a long-term physical health condition, and many also experience symptoms of low mood. Limited psychosocial support is currently available for people living with long-term physical health conditions and subthreshold depression, who are...

A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholders

Abstract Introduction Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting...

Mendelian randomisation and colocalisation reveal pleiotropic effects of the CD40/SLC12A5 locus on CD40 protein, depression, and immune disease

Abstract Inflammatory pathways are implicated in depression, but the specific immune proteins and causal variants involved remain unclear. This study investigated potential causal relationships between 91 immune-related plasma proteins and depression using generalized summary Men...

Pediatric Functional Lung Imaging: A Scoping Review

Functional lung imaging enables pulmonary parameters, including ventilation, perfusion, gas exchange, and biomechanics, to be mapped and quantified noninvasively throughout the lungs. Pulmonary function testing is generally more difficult to perform in a child in comparison to an...

Amplicon-based long-read sequencing for accurate CYP2D6 gene deletion and duplication detection using CYP2D7 as a reference gene

Abstract We developed an amplicon-based long-read sequencing approach that enables simultaneous detection of CYP2D6 single-nucleotide variants (SNVs) and copy-number variations (CNVs) in a single reaction. The SNVs of the two pseudogenes, CYP2D7 and CYP2D8, were also comprehensiv...

P1.169. Magnetic and ICG High Risk Lymph Node Mapping in Upper GI Cancer: A Safety, Feasibility and Diagnostic Performance Clinical Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Accurate localisation of high-risk lymph node (HRLN) stations in upper gastrointestinal cancer could enable tailored resection and focused ultra-staging while avoiding unnecessary lymphadenectomy...

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

ABSTRACT CEP55, a centrosomal protein frequently overexpressed in multiple cancers, is implicated in regulation of genomic instability and PI3K/AKT pathway activation, yet its role in tumor progression and the tumor microenvironment remains incompletely defined. Here, we develope...

Understanding the family planning experiences and information needs of people living with multiple sclerosis: an Australian cohort study

Purpose Good quality information on family planning is essential for people with multiple sclerosis (pwMS), yet how they receive or seek information about family planning to inform reproductive decision-making is unknown. This cohort study aimed to understand the impact of MS on...

Increased risk of early failure of multiply revised total hip arthroplasty

Aims: As the demand for revision total hip arthroplasty (rTHA) grows, understanding how successive revision procedures influence implant survivorship and patient outcomes becomes increasingly important. This study aimed to evaluate the association between revision number and impl...