Sonic Healthcare (Germany)

Applying Proteogenomics to Characterize Molecular Features Associated With a High‐Risk HOXB13 Gene Variant in Prostate Cancer Tumors

ABSTRACT The rare HOXB13 G84E variant is one of few established high‐risk prostate cancer (PrCa) variants, yet the underlying molecular mechanisms by which it drives tumor development remain unknown. Prostate tumors from six heterozygous G84E variant carriers and 18 non‐carriers...