Smart High Tech (Sweden)

Nickel-CatalyzedAsymmetric C(sp2)–PCoupling for the Direct Synthesis of the PMOP Atropisomeric PhosphineLigand

Abstract An efficient kinetic resolution of binaphthyl triflates is developed via Ni-catalyzed asymmetric C(sp2)–P cross-coupling to access substituted atropisomeric phosphines. Moreover, the phosphine framework showed superior reactivity and enantiocontrol in Pd-catalyzed asymme...