Skåne University Hospital

Decreasing Trends in Birth Prevalence and Severity of Cerebral Palsy in Sweden During 2000–2019: A Population‐Based Registry Study

AIM: To examine temporal trends in cerebral palsy (CP) birth prevalence and changes in functional severity in Sweden between 2000 and 2019. METHODS: This population-based registry study included all children with CP born in Sweden between 2000 and 2019. Annual CP birth prevalence...

Challenges and strategies in the multicultural sexual and reproductive healthcare encounter - a qualitative study on the perspectives of health professionals

BACKGROUND: Sexual and reproductive health (SRH) in Sweden is shaped by strong equity and gender-equality ideals, yet migrant patients continue to experience disparities in SRH outcomes. Social, cultural, and structural factors can complicate clinical encounters, potentially posi...

Improvement in peripheral airway function after a 12-week exercise intervention in COPD

Abstract Background Exercise is a cornerstone of chronic obstructive pulmonary disease (COPD) management and improves quality of life, exercise capacity, exacerbation frequency and survival. However, the physiological mechanisms underlying these effects remain unclear. Small airw...

PD-1 and PD-L1 Expression in Inflammatory Bowel Disease: A Paired Immunohistochemical Study

Background/Objectives: The significance of the PD-1/PD-L1 immune checkpoint pathway in inflammatory bowel disease (IBD) is highlighted by side effects from checkpoint inhibitor therapies including autoimmune enterocolitis reminiscent of IBD. Methods: This exploratory study examin...

Meeting lifestyle recommendations among cancer survivors – a cross-sectional descriptive analysis from the Swedish CArdioPulmonary BioImage study (SCAPIS)

PURPOSE: This study aimed to describe lifestyle patterns in relation to recommendations -including physical activity, diet, smoking, alcohol consumption, and sleep quality-among Swedish cancer survivors, stratified by sex and age. METHOD: A descriptive cross-sectional study was p...

Socioeconomic status and longitudinal neurocognitive outcomes following childhood brain tumour diagnosis: a Swedish national population-based cohort study

Abstract Background Lower socioeconomic status (SES) is linked to poorer neurocognitive development in the general population, but these effects in paediatric brain tumour survivors are underexplored. We examined the relationship between parental SES, clinical factors, and neuroc...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner

Abstract ESR1 mutations are a driver of endocrine therapy resistance in breast cancer, however their impact on protein signaling pathways and clinical outcomes remains poorly understood. We analyzed the transcriptomic, proteomic, and phosphoproteomic landscape of tumors harboring...

Temporal Association Between Intrathoracic Impedance and Tachyarrhythmia Occurrence

BACKGROUND: This study examined whether daily intrathoracic impedance is temporally associated with the occurrence of atrial fibrillation (AF) and ventricular tachycardia (VT). METHODS: This retrospective cohort study included 117 patients with cardiac implantable devices, follow...

Promoting psychological resilience during the perinatal period with a digital tool (the HealthyMoms4MentalHealth-app): a study protocol for a randomised controlled trial in Sweden

Abstract Background Pregnancy and childbirth are major life transitions that can significantly impact women’s mental health, with depression and anxiety being the most commonly reported. International and Swedish studies estimate that up to one in four women experience anxiety or...

Network analysis of the genetic relationships between twenty psychiatric and substance use disorders.

We sought to clarify, using network analysis, the structure of genetic risk factors for a wide range of psychiatric and substance use disorders. Using split halves (N=1,510,974), we computed the family genetic risk scores (FGRSs) for 20 psychiatric and substance use disorders ass...

MEGATRON: Reproducing the Diversity of High-Redshift Galaxy Spectra with Cosmological Radiation Hydrodynamics Simulations

We present the MEGATRON suite of cosmological radiation hydrodynamics simulations following the formation of Milky Way-mass galaxies from the earliest cosmic epochs when Population III stars form to Cosmic Noon. The suite represents the first set of cosmological simulations that...

MEGATRON: how the first stars can create an iron metallicity plateau in the smallest dwarf galaxies

We study the stellar mass-iron metallicity relation of dwarf galaxies in the new high-resolution MEGATRON cosmological radiation-hydrodynamics simulations. These simulations model galaxy formation up to z ≈ 8 in a region that will collapse into a Milky-Way-like galaxy at z = 0 ,...

MEGATRON: the impact of non-equilibrium effects and local radiation fields on the circumgalactic medium at cosmic noon

We present three cosmological radiation-hydrodynamic zoom simulations of the progenitor of a Milky Way-mass galaxy from the MEGATRON suite. The simulations combine on-the-fly radiative transfer with a detailed non-equilibrium thermochemical network (81 ions and molecules), resolv...

Fatigue in men and women 3 and 12 months after ischemic stroke: Occurrence, severity, impact on functioning, and changes over time

BACKGROUND: Although fatigue is common after stroke, there is limited knowledge about gender-specific differences, fatigue severity, impact on functioning, and how fatigue changes over time. With advanced stroke treatments and a higher proportion of mild strokes, updated knowledg...

Advanced Pulmonary Drug Delivery Systems: A Narrative Review

Pulmonary drug delivery systems have gained increasing attention as an effective strategy for the treatment of both respiratory and systemic diseases by enabling targeted, noninvasive, and efficient drug administration through the lungs, with advantages including rapid onset of a...

Babesia divergens IgG Antibodies and ABO Blood Types In Humans

Babesia is an intraerythrocytic parasite transmitted by ticks or through blood transfusion, and it can cause babesiosis with symptoms such as fever, anemia, and organ failure. The parasite is closely related to the mosquito-borne Plasmodium falciparum, which causes malaria. Sever...

ADAR1 is increased in prostate cancer progression and silencing reduces A-to-I editing and cell growth while enhancing apoptosis and adhesion

Abstract Adenosine deaminase acting on RNA 1 (ADAR1) catalyses adenosine-to-inosine (A-to-I) RNA editing and has emerged as a regulator of cell biology. Here, we investigate the expression and function of ADAR1 in prostate cancer using in vitro models and clinical patient cohorts...

Comments on the systematic review and meta‐analysis by Câmara et al. on second‐generation colon capsule endoscopy

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...