Institution
Sir Charles Gairdner Hospital
Recent research
- Health & Medicine
Taking a clinical history in adolescents and adults presenting with seizures or epilepsy
Abstract Despite advances in EEG, neuroimaging, and other diagnostic technologies, a carefully obtained clinical history remains the cornerstone of diagnosis, classification, and treatment planning. However, structured guidance on history‐taking that integrates state‐of‐the‐art e...
- BiologyOpen access
The Leukocyte Landscape Across Mouse Strains and Tissues
ABSTRACT With widespread use of mice ( Mus musculus ) in immunological research, understanding baseline immune variation between mouse models is critical. While peripheral blood immune profiles have been well‐defined, strain‐ and sex‐specific differences in leukocyte composition...
- Health & MedicineOpen access
Background Most people recover well following mild traumatic brain injury (mTBI). However, some experience persisting post-concussion symptoms (PPCS) for months or years. Our aims were (i) to evaluate the presence and impact of PPCS on return to functional activities over a 12-mo...
- Open access
ABSTRACT Background Pelvic exenteration (PE) has emerged as a viable resection strategy for locally advanced and recurrent pelvic cancers; however, it carries the burden of significant morbidity. The vertical rectus abdominis myocutaneous (VRAM) flap is a reconstructive method de...
- Health & MedicineOpen access
The PASE Study: The Prevalence and Associations of Bendopnoea in Patients with Pneumothorax
Background: We recently established that bendopnoea (breathlessness upon bending forward) is common with pleural effusion; however, it has never been reported or investigated in patients with pneumothorax. This exploratory study investigated the prevalence and clinical relevance...
- Health & MedicineOpen access
Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...
- Health & MedicineOpen access
Abstract The integration of immunotherapy into neoadjuvant treatment for triple-negative breast cancer (TNBC) has improved outcomes in some patients. Pre-clinical investigation of immunotherapy resistance in the aggressive 4T1 TNBC model has been hampered by a lack of known tumou...
- Health & MedicineOpen access
ACPSEM guideline regarding the adoption of the IAEA TRS-398 Code of Practice Revision 1
Abstract The IAEA Technical Report Series 398 Code of Practice for the determination of absorbed dose in external beam radiotherapy was endorsed at the Engineers and Physical Scientists in Medicine (EPSM) conference in 2001 and has been widely adopted in Australia and New Zealand...
- Health & MedicineOpen access
Oral Helicobacter pylori: a scoping review and pilot study on the PCR-culture detection paradox
Abstract Objective The role of the oral cavity as a reservoir for Helicobacter pylori remains controversial. This hybrid study, combining a scoping review and a pilot clinical study, aimed to synthesise global evidence on oral H. pylori detection and investigate the discrepancy b...
- Health & MedicineOpen access
Abstract Introduction Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting...
- BiologyOpen access
Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapi...
- Health & MedicineOpen access
P1.028. Disaster Management Following Hiatus Hernia Repair Post-Sleeve Gastrectomy
Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Revisional surgery to address the late complications of laparoscopic sleeve gastrectomy (such as sleeve stenosis and reflux) and concomitant proximal sleeve migration can carry significant risk....
- Health & MedicineOpen access
BACKGROUND: Lower testosterone concentrations in older men are associated with poorer health outcomes. OBJECTIVE: We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing,...
- Biology
Background Systematic reviews of randomised controlled trials with meta-analyses indicate that speech and language therapy for aphasia after stroke is effective in improving communication. However, high-quality evidence to identify an intervention’s target population (who), regim...