SingHealth

Artificial Intelligence in the Assessment and Management of Spasticity: A Scoping Review

Spasticity is a prevalent and disabling consequence of upper motor neuron disorders, yet its assessment and management remains clinically challenging. Artificial intelligence (AI) may offer opportunities to enhance the objective assessment, prediction, and management of spasticit...

Implementing reproductive carrier screening to include diverse Asian populations: insights from Singapore

Abstract Background As part of Singapore’s effort towards precision medicine tailored to Asian diversity, we describe the implementation of a nationwide reproductive carrier screening program. Using a customised 112-gene panel, targeting population-specific recessive genetic dise...

Evaluation of Intervention Strategies to Improve Follow-Up Colonoscopy After Abnormal FIT/FOBT Result

Importance Colorectal cancer is the second leading cause of cancer mortality worldwide. Early detection through screenings has been shown to improve morbidity and mortality. While fecal immunochemical test (FIT) or fecal occult blood test (FOBT) are established cost-effective scr...

Terminal discharge of the imminently dying from hospital to home: A realist evaluation

Background: Rapid terminal discharge home is increasingly prevalent, yet processes remain inconsistent and stressful for both clinicians and families. A harmonised ‘compassionate discharge’ protocol was collaboratively developed by providers across settings to improve overall exp...

Genomic and transcriptomic landscape of spread through air spaces in stage 1 lung adenocarcinoma

INTRODUCTION: Spread through air spaces (STAS) is an adverse histologic feature in early-stage lung adenocarcinoma (LUAD) incorporated into the ninth edition TNM staging. Despite its clinical significance, the molecular features underlying STAS in stage 1 LUAD remain incompletely...

The Ethics of Growth-Promoting Pharmaceuticals for Achondroplasia

In 2021, vosoritide became the first pharmaceutical approved to treat the pathophysiology of achondroplastic dwarfism. It has generated significant ethical debate. Proponents emphasize its potential to improve quality of life and functional independence, whereas critics raise con...

Healthcare Professionals’ Perspectives on Immersive Virtual Reality for Rehabilitation and Patient Engagement in a Post-Acute Community Setting: A Qualitative Descriptive Study

Background: Immersive virtual reality (VR) may support rehabilitation and patient engagement; however, little is known about how frontline healthcare professionals perceive its clinical relevance and feasibility in post-acute community care settings. This study explored healthcar...

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

The ends of human chromosomes are capped by specialized nucleoprotein structures, termed telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide resolution, uncovering ext...

The digital native fallacy: how age-based assumptions exclude young adults with chronic disease from digital health innovations

Digital health interventions often rely on a “digital native” assumption of inherent user competence and stable access. Drawing on US-based evidence, we challenge this: social media fluency does not equate to health literacy 1 , digital access is structurally unstable 2 , and ins...

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...

Challenges in accessing health information among patients with uncontrolled hypertension in Singapore: a qualitative study

Accessing health information is the crucial first step before an individual can understand, appraise, and apply it to improve their health. Health information is important for patients with chronic diseases such as hypertension, where effective self-management is essential for di...

Making decisions about hormone replacement therapy for transgender and gender diverse youth in clinical settings in Singapore: a qualitative study

Objective: The objective of this study is to explore how clinical decision-making regarding hormone replacement therapy (HRT) for transgender and gender diverse (TGD) youth takes shape within clinical encounters involving healthcare providers, TGD youth, and their parents.Methods...