Singapore-MIT Alliance for Research and Technology

Comprehensive m6A landscape from direct RNA sequencing reveals SYNPO2L RNA isoform regulation mechanisms in heart failure

Accumulating evidence suggests that epitranscriptomic regulation, particularly the m6A modification, contributes to heart failure progression. However, modification dynamics are not yet mapped and studied at base resolution and transcript isoform level. Here we use Nanopore direc...

Bidirectional Plant‐Microneedle Responses to Guide Biomaterial Design

ABSTRACT Designing biomaterials compatible with plants and specific payloads enables new technologies for precision agriculture, including targeted and dose‐controlled agrochemical delivery that overcomes the runoff, drift, and cuticular exclusion limiting conventional methods. H...

Stress-Induced Reprogramming of tRNA Epitranscriptome in the Industrially Important Yeast Komagataella phaffii

Abstract Transfer RNA (tRNA) modifications regulate codon-biased translation and enable rapid translational adaptation to environmental stresses in diverse organisms. While these mechanisms have been extensively characterized in Saccharomyces cerevisiae, little is known about the...

Strong Coupling in Bulk Nanoplasmonic Nanoplatelet Perovskite Scintillators

ABSTRACT Control of light emission underpins photonics and radiation detection. Strong coupling between excitons and confined electromagnetic modes forms light–matter states known as polaritons, enabling emission control. In scintillators, such effects have been investigated main...

Growth-dependent tRNA reprogramming and codon bias link translation to metabolic state in Enterococcus faecalis

ABSTRACT Enterococcus faecalis is a gram-positive commensal bacterium of the human gut microbiome and an opportunistic pathogen responsible for many hospital-acquired infections. Despite the clinical importance of E. faecalis , how gene and protein expression are coordinated with...

Plasmonic-enhanced lanthanide nanotransducers for mid-infrared detection

Advanced mid-infrared (MIR) detection underpins a wide range of applications from chemical sensing to thermal imaging. Conventional MIR photodetectors rely on narrow-bandgap semiconductors that typically require cryogenic cooling, whereas uncooled alternatives suffer from inheren...