Singapore General Hospital

Artificial Intelligence in the Assessment and Management of Spasticity: A Scoping Review

Spasticity is a prevalent and disabling consequence of upper motor neuron disorders, yet its assessment and management remains clinically challenging. Artificial intelligence (AI) may offer opportunities to enhance the objective assessment, prediction, and management of spasticit...

From Evidence to Practice: A Behaviourally Informed Multidisciplinary Strategy to Increase Cefazolin Prophylaxis in Joint Arthroplasty Patients with Penicillin Allergy Labels

Background: Cefazolin is recommended for surgical prophylaxis in most patients with penicillin allergy labels (PALs) but concerns over beta-lactam cross-reactivity often limit use. We evaluated a behaviourally informed, multidisciplinary antimicrobial stewardship strategy on cefa...

Dual-Energy Computed Tomography Versus Conventional Magnetic Resonance In-Phase/Opposed-Phase Imaging for Liver Fat Fraction Quantification: A Retrospective Cohort Study

Background/Objectives: Multiple imaging modalities are available for non-invasive hepatic fat quantification. We performed a hypothesis-generating methods-comparison study to compare liver fat fraction (FF) measurements obtained using magnetic resonance imaging (MRI) in-phase/opp...

Evaluation of Intervention Strategies to Improve Follow-Up Colonoscopy After Abnormal FIT/FOBT Result

Importance Colorectal cancer is the second leading cause of cancer mortality worldwide. Early detection through screenings has been shown to improve morbidity and mortality. While fecal immunochemical test (FIT) or fecal occult blood test (FOBT) are established cost-effective scr...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Gut microbiome composition and oxalate-related metabolic functions in staghorn calcium oxalate stone formers: a shotgun metagenomic analysis

To characterize gut microbiome composition and oxalate-related metabolic functions in patients with staghorn calcium oxalate (CaOx) stones using shotgun metagenomic sequencing, and to determine whether specific bacterial taxa and pathways differ from controls without known urolit...

Mind the Gap: Disparities in Education on Organ Donation and Transplantation-Results of a Global Survey.

Background: Widely accessible education on organ donation and transplantation (ODT) is a tool to reduce waiting lists, as <10% of transplant needs are met (Global Observatory on Donation and Transplantation). We aimed to assess the current state of access to education on ODT worl...

Acceptance of Organs From Deceased Donors: Results of a Global Survey.

Background: With <10% of transplantation needs being met, one contributing factor may be the potential subjectivity in transplant specialists' acceptance of organs. Such decisions, if influenced by knowledge and/or comfort gaps, warrant intervention. We assessed knowledge and com...

Exploring treatment burden and self-management experiences among adults receiving haemodialysis to inform person-centred digital care: a descriptive qualitative study

Person-centred care identifies the need to understand what matters to an individual, as opposed to what is the matter with them. Although digital technologies are increasingly used to support haemodialysis self-management, little is known about how the experiences of those receiv...

Sarcopenia in Informal Caregivers of Persons Living with Dementia: A Scoping Review

Background/Objectives: Dementia caregiving is associated with psychological stress, but the impact on caregivers’ physical health, particularly sarcopenia—the progressive loss of muscle mass, strength, and function—remains under-explored. Sarcopenia is clinically significant as a...

Terminal discharge of the imminently dying from hospital to home: A realist evaluation

Background: Rapid terminal discharge home is increasingly prevalent, yet processes remain inconsistent and stressful for both clinicians and families. A harmonised ‘compassionate discharge’ protocol was collaboratively developed by providers across settings to improve overall exp...

Genomic and transcriptomic landscape of spread through air spaces in stage 1 lung adenocarcinoma

INTRODUCTION: Spread through air spaces (STAS) is an adverse histologic feature in early-stage lung adenocarcinoma (LUAD) incorporated into the ninth edition TNM staging. Despite its clinical significance, the molecular features underlying STAS in stage 1 LUAD remain incompletely...

Peri‐operative glucagon‐like peptide‐1 receptor agonist use and outcomes: a national prospective multicentre cohort study

Summary Introduction Peri‐operative glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) use is associated with delayed gastric emptying. It is unclear what proportion of patients having anaesthetic care are receiving GLP‐1 RAs; what strategies are used in their peri‐operative man...

Efficacy of a soft robotic exoskeleton for upper-limb rehabilitation in subacute stroke inpatient rehabilitation: a randomised controlled trial

Soft robotic devices may be a useful adjunct for stroke rehabilitation by providing higher intensity training, while allowing comfort and portability compared to rigid exoskeletons. We evaluated the efficacy of a sensor-assisted soft robotic glove (SSR) during inpatient stroke re...

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

The ends of human chromosomes are capped by specialized nucleoprotein structures, termed telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide resolution, uncovering ext...

“Swab-and-Stain” Nanoparticle Assay for Detection of PBP2a-Expressing Methicillin-Resistant Staphylococcus aureus Toward Point-of-Need Environmental Surveillance

Surveillance of methicillin-resistant Staphylococcus aureus (MRSA) in the environment is crucial for reducing its transmission, particularly in hospitals, nursing homes, and high-contact public areas. Rapid Point-of-Need (PON) tools at healthcare facilities, without involving pro...

Biomechanical comparison of mini-plate and screw fixation in minimally invasive distal metatarsal osteotomy for hallux valgus

Aims To biomechanically compare the stability of mini-plate and dual-screw fixation following minimally invasive distal metatarsal osteotomy for hallux valgus, with an emphasis on early-stage stability under clinically relevant loading conditions. Methods Three fixation configura...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

P1.042. Utility of a Fenestrated Surgical Drain for the Prevention and Treatment of Esophageal Leak

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Esophageal transmural defects are associated with high morbidity and mortality. Sponge-based endoscopic vacuum therapy (EVT) is effective but costly and requires fr...

The digital native fallacy: how age-based assumptions exclude young adults with chronic disease from digital health innovations

Digital health interventions often rely on a “digital native” assumption of inherent user competence and stable access. Drawing on US-based evidence, we challenge this: social media fluency does not equate to health literacy 1 , digital access is structurally unstable 2 , and ins...