Sinai Hospital

Leveraging whole-genome sequencing to manage a Streptococcus agalactiae outbreak in a neonatal intensive care unit

OBJECTIVES: To investigate late-onset Group B Streptococcus (GBS) transmission dynamics in a neonatal intensive care unit (NICU) using whole-genome sequencing (WGS). SETTING: A 57-bed level III NICU in Toronto, Canada. PATIENTS: Neonates with late-onset GBS (LOGBS) identified, Ju...

Exercise and Thoracic Aortic Aneurysms: A Paradigm Shift Toward Informed, Personalized Activity Guidelines

Exercise is widely recognized for its cardiovascular benefits; however, its safety and role in patients with thoracic aortic aneurysms (TAAs) remains complex due to its distinctive biomechanical vulnerabilities. Fundamentally different from abdominal aortic aneurysms, TAAs develo...

Parental Refusal of the Best Treatment: Nudges and Trust in Pediatrics

More effective and less toxic therapies are welcomed by clinicians and families and are the rationale and raison d'être for well-designed clinical trials. This is especially true for life-threatening diseases like childhood cancer. When parents opt for an existing and good treatm...

Nontraumatic Osteonecrosis of the Femoral Head: An Update.

➢ Nontraumatic osteonecrosis of the femoral head should be suspected in patients who are <50 years of age who have persistent hip pain despite normal radiographs. ➢ Bilateral involvement is common; magnetic resonance imaging (MRI) of the contralateral hip is recommended. ➢ MRI is...

How Does the Time from Intraoperative Culture Harvest to Incubation Impact Culture Positivity in Orthopaedic Surgeries? A Case–Control Study

Background: Orthopaedic infections require accurate microbiological diagnosis for effective treatment. This study aimed to evaluate the impact of an accelerated protocol for culture harvesting and incubation on culture positivity rates in orthopaedic surgeries, comparing it to th...

AI at the Bedside: An Argument for a Training Wheels Approach

Bedside use of artificial intelligence (AI) platforms is increasingly common. Busy clinicians may welcome these generative AI (Gen AI) tools, which have the potential to streamline many time-consuming tasks and aid in patient care. Trainees may find them useful to quickly evaluat...

Hospital-Based Severe Maternal Morbidity Surveillance and Review

Background: Learning from promising maternal health interventions is limited by the lack of standardized outcome measures needed for their evaluation. We describe the development and utilization of Maryland’s severe maternal morbidity (SMM) surveillance by the Maryland Maternal H...