Sinai Health System

Screening for Early Endometriosis Detection (SEED): Co-development of a Symptom-Based Screening Measure for Canadian Young Adults in Primary Care

Background Many Canadians experience prolonged pain, uncertainty, and stigma before receiving an endometriosis diagnosis, with delays averaging 11 years from symptom onset. Endometriosis, defined by the presence of endometrial-like tissue outside the uterine cavity, impacts 10% o...

Conceptualizations of compassion in the context of dementia caregiving: A scoping review protocol

Background Compassion is widely recognized as a vital component of dementia caregiving, yet its conceptualization, definition, and operationalization remain inconsistent across contexts. In dementia caregiving, compassion is often conflated with empathy, emotional labor, and rela...

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...

ATAD2 is a novel regulator of myogenesis and autophagy in skeletal muscles

Abstract The nuclear protein ATAD2 (ATPase family AAA domain containing 2) is a known positive regulator of cell proliferation in various cancer types. The expression and functional roles of ATAD2 in skeletal muscle cells are unknown. In this study, we used transient and stable k...

Barriers and Facilitators in Using Personal Hearing Amplifiers from the Perspective of Healthcare Providers

Background: Hearing loss is experienced by two-thirds of hospitalized older adults and is associated with poor access to healthcare and negative health outcomes. Personal hearing amplifiers (PHAs) are evidence-based assistive devices provided in many hospitals to improve accessib...

Prevalence and Risk of Heart Failure Among Older Adults Experiencing Homelessness: A Systematic Review and Meta-Analysis

Background Understanding the prevalence and risk of heart failure (HF) among older adults is crucial for informing the design and implementation of interventions and guiding equitable healthcare delivery. Methods A systematic search was conducted in MEDLINE, Embase, Cochrane Data...

A novel use of AI for prediction of clinical deterioration in a post-acute hospital

Abstract There is a growing literature on the prediction of risk of deterioration in hospital settings, including by leveraging artificial intelligence (AI) models. However, this literature has focused on acute-care hospitals, rather than post-acute facilities, where the risk of...

An Environmental Scan of Alternate Level of Care (ALC) Policies in Ontario, Canada

Background: Alternate level of care (ALC) patients occupy hospital beds despite no longer requiring acute services, impacting patient flow and contributing to overcrowding. Ontario hospitals have updated legislation and policies to address this issue, yet protocols vary across ce...

Defining Difficult-to-Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late D2T-RA Phenotypes

Objectives Despite advances in treat-to-target strategies, a subset of rheumatoid arthritis (RA) patients remains refractory to therapy, described as difficult-to-treat RA (D2T-RA). The European Alliance of Associations for Rheumatology (EULAR) has proposed formal criteria for D2...