Sinai Health System

Defining Difficult-to-Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late D2T-RA Phenotypes

Objectives Despite advances in treat-to-target strategies, a subset of rheumatoid arthritis (RA) patients remains refractory to therapy, described as difficult-to-treat RA (D2T-RA). The European Alliance of Associations for Rheumatology (EULAR) has proposed formal criteria for D2...