Sidra Medical and Research Center

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Abstract Background Bioactive peptides (BAPs), derived from both natural and synthetic sources, are increasingly recognized as multifunctional agents with potential roles in the management of cancer and inflammatory conditions, in addition to their well‐established antimicrobial...

Screening of Attention-Deficit Hyperactivity Disorder and its associated factors among medical university students in Lebanon: A multicenter cross-sectional study

Attention-Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder that may adversely affect academic performance and well-being. Data on ADHD among Lebanese medical students are limited. This study assessed the prevalence of probable ADHD symptoms and associ...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Human iPSC-based modeling reveals coding and non-coding transcriptomic alterations associated with RFX3 deficiency in pancreatic islets

Abstract Background RFX3 is a transcription factor (TF) critical for pancreatic endocrine development. Its loss impairs β-cell differentiation, promotes enterochromaffin cell (EC) generation, and induces apoptosis. However, the role of non-coding RNAs in mediating these effects r...