Sidra Medical and Research Center

A deep-learning model based on histological images predicts survival and pathological response to neoadjuvant chemotherapy and chemoimmunotherapy in breast cancer

Abstract Background Accurate biomarkers for prognosis and selection of patients most likely to benefit from neoadjuvant chemoimmunotherapy in early breast cancer (eBC) are urgently needed. The Immune Constant of Rejection (ICR) gene expression signature, a 20-gene signature refle...

Clearing and holding: a 26-month interrupted time-series evaluation of CAMHS waiting-list redesign in Qatar

Abstract Background Clearing a waiting list is not the same as keeping it under control. Evidence on the durability of child and adolescent mental health service (CAMHS) waiting-list interventions under continuing or rising demand is limited. We evaluated an initial waiting-list...

The impact of PROgnostic SIgnatures in stage II colon cancer patients enrolled in the phase III clinical trial TOSCA: the PROSIT study

BACKGROUND: Adjuvant chemotherapy (ACT) indication in stage II colorectal cancer (CRC) remains challenging, as clinical, pathological, and ctDNA inadequately predict benefit. Immune infiltration correlates with outcome, yet transcriptional signatures have not been systematically...

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Abstract Background Bioactive peptides (BAPs), derived from both natural and synthetic sources, are increasingly recognized as multifunctional agents with potential roles in the management of cancer and inflammatory conditions, in addition to their well‐established antimicrobial...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Screening of Attention-Deficit Hyperactivity Disorder and its associated factors among medical university students in Lebanon: A multicenter cross-sectional study

Attention-Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder that may adversely affect academic performance and well-being. Data on ADHD among Lebanese medical students are limited. This study assessed the prevalence of probable ADHD symptoms and associ...

Human iPSC-based modeling reveals coding and non-coding transcriptomic alterations associated with RFX3 deficiency in pancreatic islets

Abstract Background RFX3 is a transcription factor (TF) critical for pancreatic endocrine development. Its loss impairs β-cell differentiation, promotes enterochromaffin cell (EC) generation, and induces apoptosis. However, the role of non-coding RNAs in mediating these effects r...