Sichuan Provincial Hospital of Traditional Chinese Medicine

Curcumin Delivery Systems for Inflammatory Skin Application: A Review

Curcumin (CUR) is a low-molecular-weight polyphenolic compound extracted from the rhizomes of the herb Curcuma longa. It exhibits a wide range of pharmacological activities, including anti-inflammatory, antioxidant, hypoglycemic, and antiviral effects. However, its poor solubilit...

Transdiagnostic metabolic architecture across major depressive disorder and schizophrenia: a NIMETOX systems-biology approach

Background: Major depressive disorder (MDD) is conceptualised within a neuroimmune metabolic oxidative (NIMETOX) framework. From a systems-biology perspective, related metabolic oxidative disturbances may extend across diagnostic boundaries, including schizophrenia (SCZ), but the...

Knowledge and attitudes of nurses and nursing students about Alzheimer’s disease: a systematic review and meta-analysis

With the global aging population, the burden of Alzheimer’s disease (AD) is increasing, underscoring the critical need for competent AD care. While previous studies have explored nursing personnel’s knowledge of and attitudes toward AD, a comprehensive synthesis across diverse cu...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Comparative evaluation of dental pulp and periodontal ligament stem cell sheets for rescuing periodontal-like tissue formation in cryopreserved tooth autotransplantation

Autologous tooth transplantation (ATT) is a biologically based approach for the management of tooth loss, particularly among adolescents. However, its broader application is limited by challenges associated with tooth cryopreservation and stem cell-based strategies, and current s...

Dose–response associations of the composite dietary antioxidant index and related nutrients with prevalent chronic kidney disease: NHANES 2003–2018

Oxidative stress is implicated in kidney dysfunction, but population-based evidence linking dietary antioxidant profiles to prevalent chronic kidney disease (CKD) remains limited. We examined associations of the composite dietary antioxidant index (CDAI) and selected antioxidant-...

Integrated Multi‐Omics Analysis Identifies HVCN1 as a Potential Mediator in Neuroendocrine–Tumor Interactions in Colorectal Cancer

ABSTRACT Objective To investigate associations among sleep‐related features, neuroendocrine alterations, and colorectal cancer (CRC)‐related molecular programs, and to identify candidate genes involved in hypothalamus–tumor interactions. Methods NHANES data were analyzed to asses...

SelO functions as a tumor suppressor through AMPylating Cdk5rap3

Cell fate is governed by signaling pathways involving diverse protein modifications. However, how protein AMPylation mediates signal transduction in mammalian cells remains largely unexplored. We demonstrate that the protein adenylyltransferase, SELENOO (SelO), is induced by chem...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

P1.063. Development of a Machine Learning-Based Programmed Cell Death Genes Prognostic Model for Esophagea Carcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background To use bioinformatics methods to evaluate the prognostic value of Programmed Cell Death Related Genes (PCDRGs) in esophageal carcinoma (EC), and to explore the development and immune regulatory mechanisms of...

A study on the screening of potential biomarkers for rheumatoid arthritis based on nontarget metabolomics

To explore changes in blood metabolites with rheumatoid arthritis (RA) using non-targeted metabolomics techniques, to identify potential metabolic biomarkers in RA patients. Twenty patients with rheumatoid arthritis (RA group) who attended the Sichuan Province Orthopaedic Hospita...