Sichuan Mianyang 404 Hospital

Integrated network toxicology, transcriptomic, and Mendelian randomization analyses explore potential molecular links between acrylamide exposure and clear cell renal cell carcinoma

Acrylamide is a potential carcinogen widely encountered in occupational settings and heat-processed foods. However, the potential molecular relationships between acrylamide-associated targets and clear cell renal cell carcinoma remain poorly characterized. The toxicological chara...

A retrospective cohort study of the association between triglyceride-glucose index and its derived indicators and all-cause mortality among community-dwelling adults with a history of stroke

Abstract Objective As a novel marker of insulin resistance, the triglyceride-glucose (TyG) index has been documented to correlate with mortality in coronary artery disease and heart failure. In recent years, growing attention has been paid to the relationship between the TyG inde...

Artificial intelligence across the emergency–disaster continuum: a scoping review and implications for nursing practice

Abstract Background Emergency care and disaster response are both characterised by surges in demand, time pressure and constrained resources. In this review, an emergency-disaster continuum was developed as an analytical lens for examining AI applications across routine emergency...

Semi-recumbent position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation

RATIONALE: Ventilator-associated pneumonia (VAP) is associated with increased mortality, hospital stay, and healthcare costs in critically ill patients. Although guidelines recommend a semi-recumbent position for VAP prevention, the evidence remains uncertain due to limitations i...

Efficacy and safety of five femtosecond laser platforms in cataract surgery: a network meta-analysis informing platform-specific clinical decision-making

Abstract Background To compare the efficacy and safety of five femtosecond laser platforms (FLPs) in femtosecond laser-assisted cataract surgery (FLACS) and guide clinical selection. Methods Systematic searches (PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Effects of weighted jump-squat set configuration on acute explosive performance and fatigue responses in resistance-trained men: a randomized crossover study

Weighted jump squats are commonly used to acutely enhance explosive performance, but the optimal organization of repetitions and rest intervals remains unclear. This study compared the effects of traditional, cluster, and rest-redistributed weighted jump-squat configurations on c...

Improving environmental cleaning quality and consistency in a multi-campus hospital using a computer vision-assisted mobile application: a prospective interventional study

Abstract Background Consistent environmental cleaning is essential for preventing healthcare-associated infections, yet achieving uniform standards across multi-campus hospital systems is difficult. Conventional methods, such as manual visual inspection and traditional fluorescen...

Integrative network toxicology and transcriptomic analysis identifies candidate molecular links between drinking-water disinfection by-products and prostate cancer

Disinfection by-products (DBPs) are ubiquitous contaminants generated during drinking-water disinfection and have been associated with adverse health outcomes. Although epidemiological and toxicological studies have linked long-term DBP exposure to urinary tract malignancies, the...

Finite element analysis of a novel repair device for lumbar spondylolysis

Abstract Background This study aimed to compare the biomechanical differences between a novel repair device for lumbar spondylolysis and a nail–hook internal fixation system through three-dimensional finite element analysis. Methods Three-dimensional images of L4–S1 were construc...