Sichuan Cancer Hospital

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

ABSTRACT Tumor extracellular matrix (ECM) remodeling and cell‐intrinsic mechanical properties critically limit nanoparticle (NP) delivery, yet how these multiscale biophysical cues are coordinately regulated remains unclear. Here, we identify focal adhesion kinase (FAK/ PTK2 ) as...

Patient-Reported Burden and Clinical Spectrum of Rheumatic Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy in Lung Cancer: A Real-World Cohort Study

Background: Rheumatic immune-related adverse events (R-irAEs) after immune checkpoint inhibitor (ICI) therapy in lung cancer can be difficult to distinguish from cancer-related or degenerative musculoskeletal symptoms. Methods: In this single-center retrospective cohort, we analy...

Hypoxia‐Regulating Nanozymes for Biomedicine

Hypoxic microenvironments arise when local oxygen supply fails to meet cellular demand and exert an influence on the progression of cancer, ischemic heart and brain injury, chronic inflammatory disorders, and other diseases. Conventional approaches, including oxygen delivery syst...

Development and validation of a predictive nomogram for stratifying risk in uterine mesenchymal tumors based on clinical and multiparametric ultrasound characteristics

To develop and validate a nomogram model integrating clinical and multiparametric ultrasound features for the preoperative differentiation of uterine sarcoma from atypical uterine leiomyoma. A total of 46 patients with uterine sarcoma and 239 patients with atypical uterine leiomy...

A wearable closed-loop insulin micropump toward a miniaturized artificial pancreas for diabetes

The application of a fully autonomous artificial pancreas faces fundamental constraints from the bulky mechanical drives of conventional insulin pumps and the spatially separated glucose sensing unit. Herein, we report a wearable closed-loop insulin micropump that enables a minia...

Digital symptom management interventions for patients with head and neck cancer during peri-chemoradiotherapy: a scoping review using the UK Medical Research Council Framework

Patients with head and neck cancer experience a substantial symptom burden that severely affects their quality of life during peri-chemoradiotherapy. Digital health interventions offer a promising approach for symptom management. However, such interventions are often hindered by...

A preliminary evaluation of [¹⁸F] FDG and [¹⁸F] AlF-NOTA-Pentixafor PET/CT in gastric MALT lymphoma

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent B-cell neoplasm with variable uptake on [¹⁸F] FDG PET/CT, limiting its clinical utility. [¹⁸F] AlF-NOTA-Pentixafor ([¹⁸F] Pentixafor), a novel PET tracer targeting the chemokine receptor CXCR4, may serve as...

Association between circulating tumor DNA and the prognosis of solid tumor patients receiving neoadjuvant therapy: a meta-analysis

Abstract Background Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker in solid tumors, yet its prognostic value following neoadjuvant therapy (NAT) warrants systematic validation. Method This study systematically searched databases such as PubMed, Emb...

Three‐Dimensional Collagen Microenvironment Activates NF ‐ κB /Stat3 Axis to Promote Cancer Chemoresistance and Partial EMT in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) remains a leading cause of cancer mortality worldwide, with treatment resistance posing a major clinical challenge. The tumor microenvironment, particularly the three-dimensional (3D) extracellular matrix architecture, plays a critica...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Precision localization of the anus using a smart defecation assistance system based on the YOLOv11n model

BackgroundExisting defecation-assistance devices generally lack automated anal localization and image-based screening for conditions that may preclude probe operation.ObjectiveTo develop and evaluate an image-based method for anal localization and abnormal-region detection in an...

Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design

PD-1/PD-L1 blockade can produce durable tumor control, yet primary, adaptive, and acquired resistance remain common. Existing accounts often catalogue resistance by cellular compartment, obscuring the coordinated nature of tumor adaptation. Here, we introduce immune-pressure redi...

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated cal...

MUCL1 functions as a tumor suppressor in skin melanoma by inhibiting epithelial–mesenchymal transition

This study aims to analyze the global burden of skin melanoma from 1990 to 2021 and explore the clinical significance and mechanistic role of Mucin-Like Protein 1 (MUCL1) in the metastasis of skin melanoma. Global burden data from 1990 to 2021 were extracted from the Global Burde...

Extraventricular neurocytomas stratified by tumor location and histological subtype: clinical features, radiology, pathology, and prognosis

Abstract Objective To compare the differences in clinical manifestations, imaging features, histological characteristics, and prognostic outcomes of extraventricular neurocytomas (EVNs) based on tumor location (parenchymal vs. sellar) and histological subtype (typical vs. atypica...

Development and internal validation of a nomogram for visualising multidimensional correlates of baseline suicide‑attempt history among hospitalized adolescents and young adults with mental disorders

Suicide is prevalent among adolescents and young adults with mental disorders (AYAMD). Identifying factors associated with suicide‑attempt history and characterising risk profiles are essential for targeted suicide prevention in this high‑risk inpatient population. The study incl...

Robustness of 4D-optimized intensity-modulated proton radiation therapy and proton arc radiation therapy for stereotactic arrhythmia radio-ablation against cardiorespiratory motion

Background Stereotactic arrhythmia radioablation (STAR) is an emerging noninvasive treatment for refractory ventricular tachycardia. Proton therapy offers dosimetric advantages, but pencil-beam scanning is motion-sensitive. This study used an extended cardiac-torso (XCAT)-based 4...

The IER5L–AK2 axis drives aggressive behavior in triple-negative breast cancer

Breast cancer is the most frequently diagnosed malignancy in women worldwide. Triple-negative breast cancer (TNBC) has particularly poor outcomes, largely due to the lack of effective therapeutic targets. Here, we investigated the expression pattern, functional relevance, and pot...

Cost-effectiveness analysis of durvalumab combined with tremelimumab versus sorafenib as first-line treatment for unresectable Hepatocellular carcinoma in China: a dual-model approach utilizing partitioned survival and markov models

Abstract Background Hepatocellular carcinoma (HCC) is a major contributor to global cancer-related mortality, with the majority of patients diagnosed at unresectable stages. The STRIDE regimen (tremelimumab plus durvalumab) demonstrated superior survival benefits over sorafenib i...

Efficacy and safety of five femtosecond laser platforms in cataract surgery: a network meta-analysis informing platform-specific clinical decision-making

Abstract Background To compare the efficacy and safety of five femtosecond laser platforms (FLPs) in femtosecond laser-assisted cataract surgery (FLACS) and guide clinical selection. Methods Systematic searches (PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov...