Sichuan Cancer Hospital

P1.063. Development of a Machine Learning-Based Programmed Cell Death Genes Prognostic Model for Esophagea Carcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background To use bioinformatics methods to evaluate the prognostic value of Programmed Cell Death Related Genes (PCDRGs) in esophageal carcinoma (EC), and to explore the development and immune regulatory mechanisms of...

P1.067. Multinational Comparison of Surgical Approaches and Postoperative Outcomes in Esophageal Cancer: An International Multicenter Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophagectomy for esophageal cancer carries substantial morbidity, yet the extent to which institutional surgical strategy—encompassing operative approach, lymphadenectomy extent, and neoadjuvant...

P1.071. Perioperative Patient-Reported Outcomes After Robot-Assisted Versus Conventional Minimally Invasive Esophagectomy for Esophageal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Robot-assisted minimally invasive esophagectomy (RAMIE) is increasingly adopted, yet comparative patient-reported outcome (PRO) data against conventional minimally invasive esophagect...

P1.066. Prognostic Equivalence of ypN and pN Staging in Esophageal Cancer After Neoadjuvant Therapy: A Multicenter Cohort Study of 2,545 Patients

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Current staging systems apply ypN and pN categories interchangeably after neoadjuvant therapy plus esophagectomy; however, their prognostic equivalence has not been rigorously established. We inv...

P1.065. Lymph Node Yield as a Prerequisite for Prognostic Superiority of Ratio-Based Nodal Staging in Esophageal Cancer: A Multi-Institutional Validation Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) have been proposed as yield-independent alternatives to pN staging for esophageal cancer. However, their prognostic superiority...

P1.062. Discovery of Novel Dual-Target Inhibitors for EGFR and PIK3CA From Natural Products via Machine Learning and Molecular Simulation

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background With the advancement of personalized medicine, multi-target drug development has garnered significant attention, particularly for complex diseases such as cancer. This study aims to identify potential dual-t...

P1.064. Limitations of Preoperative Prediction Models for Complications After Esophagectomy: A Multi-Center Analysis

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Preoperative risk stratification for esophagectomy complications relies on clinical prediction models; however, their discriminative performance in multi-institutional settings remains poorly def...

P1.155. Impact of Lymphaticvessel Invasion on Prognosis in Patients With Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Immunochemotherapy: A Multicenter Retrospective Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Prognostic stratification remains inadequate in patients with locally advanced esophageal squamous cell carcinoma (ESCC) following neoadjuvant immunotherapy combined with chemotherapy (NICT). Thi...

P1.061. Anti-Tumor Effects of Pinellia Ternata on Esophageal Squamous Cell Carcinoma: Evidence From Patient-Derived Organoid Models

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal malignancies worldwide, with limited therapeutic options for advanced-stage patients. Pinellia ternata (Banxia), a traditional Chinese...

P1.113. Optimization of Cervical Lymph Node Ultrasound Partitioning in Esophageal Cancer: A Cross-Sectional Survey of Surgeons and Ultrasound Physicians in China

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background Accurate ultrasound evaluation of cervical lymph nodes (LNs) is essential for staging and treatment planning in esophageal cancer, particularly for decisions regarding thre...

P1.154. Delayed Unexplained Hemorrhage After Esophagectomy: Insights From a Nationwide Multicenter Questionnaire-Based Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Delayed unexplained postoperative hemorrhage after esophagectomy is a rare complication. Due to its low incidence, existing reports are limited, and high-qualit...

P1.072. Impact of Neoadjuvant Therapy on Survival After Esophagectomy for Squamous Cell Carcinoma: An International Multicenter Propensity Score Analysis

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The survival benefit of neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC) remains controversial, as landmark trials were conducted predominantly in adenocarcinoma populations. This st...

P1.070. Exploring the Association Between Month of Esophagectomy and Long-Term Survival Outcomes : a Large-Scale Survival Study Combined Questionnaire Survey Analysis

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophageal cancer remains a significant global health burden. While surgical and oncologic factors influencing survival after esophagectomy are well studied, the potential im...

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives

Lung cancer remains a leading cause of cancer-related deaths worldwide. Despite advances in targeted therapy and immunotherapy, treatment outcomes are often constrained by tumor heterogeneity and the complex tumor microenvironment. Recent studies highlight the critical role of th...