Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

The Application Potential and Future Challenges of Plant-Derived Exosome-like Nanoparticles in the Treatment of Liver Diseases

Liver disease is a serious global health challenge, with high morbidity and mortality that put significant socioeconomic stress on society. Despite therapeutic advances, current regimens have been limited by rapid drug resistance and insufficient targeting accuracy, and there is...

VGLL4 Suppresses Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells Through Modulation of Hippo/YAP and Wnt/β-Catenin Signaling Pathways

Background/Objectives: Clear cell renal cell carcinoma (ccRCC), the most common and aggressive subtype of kidney cancer, continues to face challenges in early diagnosis and treatment, driving the need for reliable biomarkers and therapeutic targets. Vestigial-like family member 4...

Body roundness index and other anthropometric indices in relation to incident myocardial infarction: a cohort study from the UK Biobank

Traditional anthropometric measures like body mass index (BMI) and waist circumference (WC) inadequately reflect body fat distribution. Body roundness index (BRI), a derived anthropometric index mathematically equivalent to waist-to-height ratio (WHtR) after removing non-function...

Preoperative fibrinogen-to-albumin ratio and prediction of muscle-invasive and locally advanced upper tract urothelial carcinoma: development and internal temporal validation of a nomogram

Preoperative staging of upper tract urothelial carcinoma (UTUC) relies on cross-sectional imaging and ureteroscopic biopsy, both with recognised limitations for predicting muscle invasion. We compared the fibrinogen-to-albumin ratio (FAR) with four other inflammation–nutrition in...

Brain care score and retinal health: structural and metabolic insights from the UK Biobank

The retina is an extension of the central nervous system and a recognized indicator of systemic health, yet the link between the brain care score (BCS) and retinal health remains unclear. In this study, we aimed to assess the associations of BCS with retinal layer thickness and r...

Telemedicine and physicians’ work–life integration: a scoping review of benefits, risks, and organizational conditions

Work–life integration is central to physician well-being, workforce retention, and sustainable healthcare delivery. Telemedicine may increase flexibility and autonomy but can also extend clinical work beyond scheduled hours and blur work–life boundaries. We conducted a scoping re...

Transdiagnostic metabolic architecture across major depressive disorder and schizophrenia: a NIMETOX systems-biology approach

Background: Major depressive disorder (MDD) is conceptualised within a neuroimmune metabolic oxidative (NIMETOX) framework. From a systems-biology perspective, related metabolic oxidative disturbances may extend across diagnostic boundaries, including schizophrenia (SCZ), but the...

Correlation of bevacizumab relative dose intensity with first-line treatment outcomes in advanced epithelial ovarian cancer

Objective: To evaluate the association between bevacizumab relative dose intensity (RDI) and first-line treatment outcomes in advanced epithelial ovarian cancer.Methods: We retrospectively analyzed 72 patients treated with first-line bevacizumab plus paclitaxel-platinum chemother...

Longitudinal Study on Post‐Traumatic Stress Disorder, Anxiety, and Depression Among Medical Staff in China

ABSTRACT Background Evidence of the longitudinal relationship between anxiety, depression, and post‐traumatic stress disorder (PTSD) is not uniform. This study aimed to explore the dynamic changes, independent factors, and bidirectional predictive relationships of anxiety, depres...

Multi-omics Mendelian randomization analysis prioritizes DNA methylation-related mitochondrial genes in congenital heart disease

Mitochondrial dysfunction has been increasingly recognized as a key pathophysiological contributor to congenital heart disease (CHD), yet its underlying genetic causal effects remain incompletely characterized. This study aimed to investigate the genetically supported association...

Differential circadian time modulates of dentate gyrus and CA1 excitation-inhibition balance and seizure threshold

Abstract Circadian rhythms regulate seizure threshold and neuronal excitability in epilepsy. Temporal lobe seizures tend to arise more frequently during the diurnal phase relative to the nocturnal phase, yet dentate gyrus (DG) granule cells display elevated intrinsic excitability...

Development of a core competency evaluation indicator system for weight management nurses: a Delphi and analytic hierarchy process study

Weight management services increasingly require nurses to contribute to risk assessment, behavioural support, multidisciplinary coordination and long-term follow-up. However, there is limited consensus on the competencies required for nurses working in this emerging field. This s...

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumo...

A self-driven probiotic nanosystem reshapes extracellular matrix by knockdown of DDR1 for enhanced tumor immunotherapy

Immunotherapy represents a promising therapeutic approach for tumor suppression, yet its efficacy is significantly limited by the immunosuppressive extracellular matrix (ECM) characteristic of solid tumors. To achieve simultaneous ECM remodeling and immune activation within a sin...

Correlation between CYP2B6 exonic gene polymorphisms and efavirenz plasma concentrations in Yi ethnic HIV/AIDS patients: a study from Sichuan province, China

Polymorphisms in the CYP2B6 Gene significantly impact efavirenz (EFV) metabolism and plasma levels, resulting in variability in both treatment effectiveness and toxicity among individuals. In this study, we aimed to evaluate the relationship between the CYP2B6 polymorphisms and t...

Improving environmental cleaning quality and consistency in a multi-campus hospital using a computer vision-assisted mobile application: a prospective interventional study

Abstract Background Consistent environmental cleaning is essential for preventing healthcare-associated infections, yet achieving uniform standards across multi-campus hospital systems is difficult. Conventional methods, such as manual visual inspection and traditional fluorescen...

Multiomics Insights Into AL Amyloidosis

ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor...

Stromal Cells Recruitment by Sono‐Piezoelectric/Pyroelectric Peptide Hydrogels Promotes Bone Regeneration After Postsurgical Osteosarcoma Recession: A Real‐World‐Matched Study

ABSTRACT Currently, the elimination of postsurgical osteosarcoma (OS) and defect repair are still separately explored, which is unlike real‐world clinical scenarios. Inadequate bone marrow stromal cells (BMSCs) compromise their repair and antitumor efficiencies. Here, PFSSTKT (PF...

The Visual System in Alzheimer’s Disease: A Multilevel Review of Pathology, Monitoring, and Intervention

Alzheimer’s disease (AD) extends beyond the brain to the visual system, offering a promising window for pathology, monitoring, and intervention. This review synthesizes evidence on AD-related visual impairments across molecular, cellular, circuit, and cortical levels. We examine...

Retrospective analysis of postoperative complications and risk factors in middle ear surgery

Background Postoperative complications following middle ear surgery present ongoing challenges despite advances in surgical techniques. A comprehensive analysis of complication patterns, associated risk factors, and their interactions with patient comorbidities is needed to impro...