Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Efficient Colon Cancer Immunogene Therapy by Hydrogel Ball Loaded With Two Types of Cell Membrane‐Coated Nanoparticles

ABSTRACT Biomimetic technology has high potential for enhancing cancer immunogene therapy. Cell membrane‐coated nanoparticles (CMNPs) obtain extra targeting, recognition, and signaling transduction functions. However, a single kind of CMNPs is limited when facing complicated tumo...

Development of a core competency evaluation indicator system for weight management nurses: a Delphi and analytic hierarchy process study

Weight management services increasingly require nurses to contribute to risk assessment, behavioural support, multidisciplinary coordination and long-term follow-up. However, there is limited consensus on the competencies required for nurses working in this emerging field. This s...

A self-driven probiotic nanosystem reshapes extracellular matrix by knockdown of DDR1 for enhanced tumor immunotherapy

Immunotherapy represents a promising therapeutic approach for tumor suppression, yet its efficacy is significantly limited by the immunosuppressive extracellular matrix (ECM) characteristic of solid tumors. To achieve simultaneous ECM remodeling and immune activation within a sin...

Correlation between CYP2B6 exonic gene polymorphisms and efavirenz plasma concentrations in Yi ethnic HIV/AIDS patients: a study from Sichuan province, China

Polymorphisms in the CYP2B6 Gene significantly impact efavirenz (EFV) metabolism and plasma levels, resulting in variability in both treatment effectiveness and toxicity among individuals. In this study, we aimed to evaluate the relationship between the CYP2B6 polymorphisms and t...

Improving environmental cleaning quality and consistency in a multi-campus hospital using a computer vision-assisted mobile application: a prospective interventional study

Abstract Background Consistent environmental cleaning is essential for preventing healthcare-associated infections, yet achieving uniform standards across multi-campus hospital systems is difficult. Conventional methods, such as manual visual inspection and traditional fluorescen...

Multiomics Insights Into AL Amyloidosis

ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor...

Stromal Cells Recruitment by Sono‐Piezoelectric/Pyroelectric Peptide Hydrogels Promotes Bone Regeneration After Postsurgical Osteosarcoma Recession: A Real‐World‐Matched Study

ABSTRACT Currently, the elimination of postsurgical osteosarcoma (OS) and defect repair are still separately explored, which is unlike real‐world clinical scenarios. Inadequate bone marrow stromal cells (BMSCs) compromise their repair and antitumor efficiencies. Here, PFSSTKT (PF...

The Visual System in Alzheimer’s Disease: A Multilevel Review of Pathology, Monitoring, and Intervention

Alzheimer’s disease (AD) extends beyond the brain to the visual system, offering a promising window for pathology, monitoring, and intervention. This review synthesizes evidence on AD-related visual impairments across molecular, cellular, circuit, and cortical levels. We examine...

Retrospective analysis of postoperative complications and risk factors in middle ear surgery

Background Postoperative complications following middle ear surgery present ongoing challenges despite advances in surgical techniques. A comprehensive analysis of complication patterns, associated risk factors, and their interactions with patient comorbidities is needed to impro...