Siberian Branch of the Russian Academy of Sciences

Circulating anti-Ro/SSA-antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis

Abstract Backgrounds Accumulating evidence indicates that anti-Ro/Sjögren’s syndrome-related antigen A(SSA)-antibodies, specifically the anti-Ro/SSA-52kD subtype, can promote heart rate-corrected QT interval(QTc) prolongation by inhibiting the hERG-K+ channel. However, the numero...

Efficiency Improvement and SEM Visualization of Enzymatic Hydrolysis-Based Valorization of Oat Hulls

The utilization of agro-industrial waste in the bioeconomy is crucial for reducing the environmental impact. This study investigated the valorization of a common oat processing waste—oat hulls—using enzyme preparations of different origin and enzyme cocktails based on them. Oat h...

Design, Synthesis,and Evaluation of Alkoxyamine AnticancerProdrugs Bearing Galactoside as an Enzyme-Activated Trigger

Abstract Enzyme-induced cytotoxicity can be considered the main challenge in modern cancer therapy that provides unique opportunities for targeted apoptosis. To address this challenge, we implemented enzyme-triggered activation of alkoxyamine–galactose conjugates with the formati...

Enhancing knowledge of non-target tortricid fauna via pheromone monitoring of the quarantine fruit pest Grapholita molesta (Lepidoptera: Tortricidae) in Russia

The oriental fruit moth, Grapholita molesta (Busck, 1916), is an East Asian fruit pest that has spread to both hemispheres causing significant economic losses. In some countries, including Russia, it is considered a quarantine species which occurence and spread are monitored usin...

Enhancing knowledge of non-target tortricid fauna via pheromone monitoring of the quarantine fruit pest Grapholita molesta (Lepidoptera: Tortricidae) in Russia

The oriental fruit moth, Grapholita molesta (Busck, 1916), is an East Asian fruit pest that has spread to both hemispheres causing significant economic losses. In some countries, including Russia, it is considered a quarantine species which occurence and spread are monitored usin...

Starch as a Polymer-Based Medium Modifier to Analyze Enzyme Activity under Conditions Close to Intracellular Media: Butyrylcholinesterase as a Model Enzyme

Abstract The study demonstrates the possibility of using starch to model macromolecular crowding and intracellular medium. A kinetic approach is used to reveal specific functioning of butyrylcholinesterases from different sources in the starch medium. In the study solutions, the...

Chemical Features of Rare-Earths Accessory Minerals in the Lower–Middle Cambrian Terrigenous Rocks from the Argun Series of the Northwestern Part of the Argun Superterrane as Indicators of the Sources

Abstract The paper presents the results of the chemical study of rare-earth accessory minerals of the Lower–Middle Cambrian terrigenous rocks of the Bystraya Formation and the Ernichny Unit of the Argun Series of the Argun Superterrane. The chemical analysis of monazite, xenotime...