Shuguang Hospital

Association between hippocampal ferroptosis-related changes and behavioral alterations in CCI rats with neuropathic pain

This study aimed to characterize behavioral alterations induced by chronic constriction injury (CCI) of the sciatic nerve and hippocampal ferroptosis in rats and to explore the association between hippocampal ferroptosis and behavioral changes accompanying neuropathic pain (NP)....

From baseline levels to cumulative exposure and longitudinal trajectories: estimated glucose disposal rate and incident cardiometabolic multimorbidity among middle-aged and older adults in the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS)

Abstract Background Insulin resistance is implicated in the development of cardiometabolic multimorbidity (CMM), but evidence regarding the associations of baseline, cumulative, and longitudinal patterns of estimated glucose disposal rate (eGDR) with incident CMM remains limited....

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

A dual role of PIEZO2 in neuropathic pain: driving peripheral sensitization and enabling mechanical loading-induced analgesia

Mechanotherapy, a form of mechanical loading (ML), effectively relieves tactile allodynia-associated neuropathic pain by targeting sensitization points stimulated by PIEZO2, a mechanosensitive ion channel. However, the molecular mechanisms underlying peripheral sensitization and...