Shriners Hospitals for Children - St. Louis

Delivery of miR-181a/b-1 enhances endochondral fracture repair by targeting PDK4 and regulating mitochondrial metabolism

We previously reported an in vitro pro-osteogenic function for miR-181a/b-1, in part, via increasing mitochondrial metabolism. The goal of this study was to determine the effect of miR-181a/b-1 on bone repair in vivo, and to discover metabolism-related mechanisms. Here we show th...