SHOWA Medical University Hospital

Reproducibility of the Cepstral Spectral Index of Dysphonia in Tracheoesophageal Speech and Exploratory Associations with Clinical Communication Measures

Background/Objectives: The Cepstral Spectral Index of Dysphonia (CSID) was developed for laryngeal dysphonia. We evaluated task-specific reproducibility in tracheoesophageal (TE) speech and associations with communication measures and surgical/anatomical configuration. Methods: F...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

Seated Versus Standing Endoscopic Retrograde Cholangiopancreatography: Association With Operator Fatigue and Pain

Background and study aims Endoscopic retrograde cholangiopancreatography (ERCP) is a physically demanding procedure for operators that can provoke musculoskeletal symptoms. However, burden reduction and operating performance from a seated operating posture have not been establish...

Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI

BackgroundThe safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. MethodsWe conducted a multicenter, open-label, randomized trial in Japan i...

Long-term prescribing patterns of hormone therapy and concomitant medications among women with menopausal disorders: a 20-year retrospective database study in Japan

Abstract Background Hormone therapy is an effective treatment for menopausal symptoms, but its use has changed substantially since the Women’s Health Initiative report. Long-term real-world data on hormone therapy and concomitant medication prescribing in Japan remain limited. Me...

Effectiveness of Clazosentan Combined with Ozagrel for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Comparative Study

Abstract Clazosentan, a selective endothelin A receptor antagonist, has recently emerged as an essential therapy for aneurysmal subarachnoid hemorrhage (aSAH) in Japan. However, evidence regarding combination therapy with adjunctive agents remains unclear. We retrospectively comp...

Longitudinal Stent Malapposition After Microcatheter Removal Is Associated With Incomplete Occlusion After Pipeline Flow Diversion

BACKGROUND AND OBJECTIVES: Flow diversion is an established treatment strategy for intracranial aneurysms; however, incomplete aneurysm occlusion remains a clinically relevant challenge. Adequate stent-vessel wall apposition is considered critical for aneurysm healing, yet the im...