Shizuoka General Hospital

Clinical applicability of cystatin C-based renal function assessment and HPLC-based therapeutic drug monitoring for predicting cefepime overexposure

Abstract Background Cefepime (CFPM)-associated neurotoxicity is linked to elevated plasma concentrations, particularly in patients with impaired renal function. Although cystatin C-based estimated glomerular filtration rate (eGFRcys) has been proposed as a potentially superior ma...