Shinshu University

Irrational health beliefs as barriers to health behaviors: development and validation of a brief scale in a Japanese population

Health communication and public health research has shown that providing accurate, evidence-based information does not necessarily lead to appropriate health decisions or behaviors. Cognitive biases and irrational health beliefs may contribute to this gap by shaping how individua...

Daidzein treatment exerts antioxidant effect via SIRT3–FOXO3a axis activation

Abstract Metabolic dysfunction-associated progression of steatotic liver disease is closely associated with lipotoxicity-induced oxidative stress and inflammation. This study investigated whether daidzein, a major soy isoflavone, protects hepatocytes against free fatty acid-induc...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Atypical ovarian fibroma and thecoma mimicking malignancy: clue for differentiation from malignant solid tumors

Abstract Purpose To evaluate the characteristic findings of ovarian fibroma and thecoma (FT) with atypical magnetic resonance imaging (MRI) findings that mimic malignancy and to validate the improvement in diagnostic performance in differentiating between FTs and malignant solid...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Dynamic changes in total hemoglobin concentration in the frontal region during motion-based video gameplay in patients with Duchenne muscular dystrophy: a pilot study using portable near-infrared spectroscopy (NIRS)

OBJECTIVE: This exploratory study aimed to investigate the changes in frontal hemoglobin concentration during motion-based video gaming in patients with Duchenne muscular dystrophy (DMD) and to provide preliminary findings regarding the immediate effects of video gaming on cognit...

HDAC11 and COMP Modulate Breast Cancer Cell Phenotypes and Osteoclastogenic Responses in a Co-culture Model

Background: Cartilage oligomeric matrix protein (COMP) interacts with stromal interaction molecule 1 (STIM1). Both COMP and histone deacetylase 11 (HDAC11) are highly expressed in breast cancer cells (BCC). Given the reported inhibitory effect of HDAC3 on COMP acetylation, HDAC11...

Evaluation of a lead-loaded plastic scintillator for next-generation positron emission tomography detectors using Geant4 simulation

Lead-loaded plastic scintillators are promising candidates for next-generation positron emission tomography (PET) detectors owing to their short fluorescence decay times, high machinability and low production cost. However, their γ-ray detection performance has not been fully qua...

NOTCH1 activating variants identify a high-risk subgroup of adenoid cystic carcinoma in a nationwide Japanese cohort

Abstract Adenoid cystic carcinoma (ACC) follows a heterogeneous clinical course, and because systemic therapies have limited efficacy, active surveillance is offered to selected patients, yet no validated molecular biomarker guides the choice between surveillance and intensive tr...

Revisiting Graphite Electrodes for Electric Arc Furnaces: Three‐Dimensional Microstructural Heterogeneity as a Design Parameter for Fracture Resistance

ABSTRACT Graphite electrodes are widely used in electric arc furnaces due to their high mechanical stability, electrical conductivity, and thermal resistance. Early detection and understanding of fracture mechanisms are therefore essential to mitigating catastrophic failures, sav...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Complement profiling and neutrophil single-cell analysis reveal inflammation via the classical complement pathway in Behçet’s syndrome

Behçet’s syndrome (BS) is a systemic immune-mediated disorder characterised by recurrent mucocutaneous, skin, and ocular inflammation, with severe neurological, vascular, or gastrointestinal involvement in some individuals. Although neutrophilic inflammation is considered central...

The equalities of interleaving distances and cohomology interleavings of spaces over $$BS^1$$

Abstract The cohomology interleaving distance (CohID) is defined and considered in the category of persistent differential graded modules over a field. As a consequence, we show that, in the category, the distance coincides with the homotopy commutative interleaving distance , th...

Hybrid Silk Fibroin/Poly(lactic acid) Macromer Nanogels for Advanced Drug Delivery: Influence of Organic and Silsesquioxane Crosslinker Topologies on Molecular Organization and Physicochemical Properties

Abstract Molecular orientation and structural topology play critical roles in determining the performance of biomacromolecular nanocarriers for controlled drug delivery. Herein, the influence of organic and silsesquioxane crosslinker topologies on hybrid nanogels composed of an a...

High‐Throughput Integration of Functional Powder Materials into Industrial Fiber Sheets via Roll‐to‐Roll Electrostatic Assembly

ABSTRACT Functional powder materials, including emerging photocatalysts and porous materials, can be incorporated into high‐surface‐area fiber sheets for industrial applications such as hydrogen production and water treatment. Although this can be achieved using electrostatic lay...

H I Absorbers as Beacons of Hidden Structure at z ~ 3: Multi-Component, Metal-Rich Absorption System near a Protocluster

Abstract H i gas traces the large-scale structure and provides the primary fuel for star formation. High-z protoclusters are ideal laboratories to study how H i gas is accreted and consumed during the formation of the most massive structures in the Universe. However, much remains...

Age-stratified clinical interpretation of AWGS2025 sarcopenia criteria in head and neck cancer treated with definitive chemoradiotherapy: Comparison with AWGS2019

OBJECTIVE: The AWGS2025 update extends sarcopenia diagnosis to adults aged 50-64 years, requires concurrent low muscle mass and low muscle strength, and introduces BMI-stratified muscle mass thresholds. We aimed to examine how these changes alter case identification in patients w...

Pinwheel Scheduling with Real Periods

For a sequence of tasks, each with a positive integer period, the pinwheel scheduling problem involves finding a valid schedule in the sense that the schedule performs one task per day and each task is performed at least once every consecutive days of its period. It had been conj...

Controlling Valence Band for Cu2Sn0.38Ge0.62S3 Particles via Li Substitution at Cu Sites

Abstract Cu2(Sn,Ge)S3 (CTGS) is a promising near-infrared-responsive photocathode material whose conduction band minimum can be tuned by varying the Sn/Ge ratio, whereas direct control of the valence band maximum (VBM) remains challenging because of the large Cu 3d contribution t...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...