Shimane University

New concept of maxillary distraction in adolescent patients with cleft lip and palate

Objectives: This study aimed to evaluate the clinical outcomes of intraoral maxillary distraction osteogenesis (DO) as a staged treatment strategy in adolescent patients with cleft lip and/or palate (CLP), severe maxillary hypoplasia, and midfacial growth deficiency. Patients and...

Ise Bay Reanalysis (IBRA): a 12-year ecological hydrodynamic reanalysis dataset for Ise Bay, Japan

Abstract. Reanalysis datasets based on coupled ocean circulation and ecosystem models are essential tools for understanding coastal environmental variability and supporting water quality management. However, the development of such datasets for highly enclosed coastal systems rem...

Relaxor Ferroelectric Behavior on Ag-Substituted K 5 Nb 9 O 25 (= (5/6) K 6 Nb 10.8 O 30 ) Single Crystals

Single crystals of Ag-substituted K 5 Nb 9 O 25 , which belongs to the partially filled tetragonal tungsten bronze (space group P4/mbm), were prepared by the AgNbO 3 flux method. Dielectric constant ε′, ac electrical conductivity σ, and a pyroelectric charge Δp were measured over...

Third generation Calphad: A case study of the Fe–Cr–Ni system and its binary subsystems

Thermodynamic descriptions of the binary Fe–Cr, Cr–Ni and Fe–Ni systems are evaluated in the present work using the most recent third generation Calphad models. The assessment incorporates formation energies of ordered fcc and bcc and σ compounds obtained from Density Functional...

Skin toxicity and effectiveness of first-line enfortumab vedotin plus pembrolizumab for urothelial carcinoma: a prospective multicenter real-world study in Japan

Background Skin toxicity is a common adverse event associated with enfortumab vedotin plus pembrolizumab (EVP) but its association with treatment outcomes remains unclear. We aimed to evaluate this association in patients with locally advanced or metastatic urothelial carcinoma (...

Layer-Oriented Lateral Superior Approach for Robotic Right Hemicolectomy: A Novel Embryology-Based Strategy and Initial Clinical Outcomes

Background: Complete mesocolic excision (CME) with D3 lymphadenectomy is an oncologically established procedure for right-sided colon cancer; however, the optimal dissection plane and surgical approach remain controversial. We developed a novel layer-oriented lateral superior app...

Pd(II)-Templated End-to-End Cyclization of Doubly N-Confused Bilatrienes: A Stable Singlet Diradicaloid Dye with Efficient Absorption across the Solar Spectrum

Abstract We report a highly stable singlet diradicaloid (Pd1-dimer), formed through a Pd(II)-templated end-to-end cyclization of a linear N-confused bilatriene (1). This unique Pd-bridged double-loop complex exhibits an open-shell singlet diradicaloid ground state with an extreme...

Near‐Micron Single‐Crystalline Mn‐Rich Cathodes With Exceptional Cycling Stability

ABSTRACT Achieving high‐energy‐density and long‐term cycling stability in Mn‐redox‐based cathodes is a critical step toward advancing Ni‐ and Co‐free Li‐ion chemistries to diversify supply chains and lower battery costs. Here, we demonstrate an unusually high performance benchmar...

Sodium–Glucose Cotransporter 2-Mediated Glucose Uptake Contributes to Glycogen Accumulation in Clear Cell Renal Cell Carcinoma: Implications for Clear Cell Morphology and Potential Therapeutic Relevance

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the functional von Hippel–Lindau (VHL) complex and distinctive clear cell morphology associated with intracellular glycogen and lipid accumulation. However, the mechanism underlying glycogen storage remains uncle...

A case of renal hypouricemia type 1 associated with compound heterozygous URAT1/SLC22A12 variants A209V and F379L: clinical evidence for their pathogenic significance

Abstract Renal hypouricemia (RHUC) is an inherited renal tubular disorder characterized by low serum uric acid levels and excessive urinary uric acid excretion due to impaired urate reabsorption in proximal tubules. Type 1 RHUC (RHUC1) is caused by pathogenic variants in URAT1/SL...

The Association Between Circulating Myostatin and Skeletal Muscle Mass Varies by Nutritional–Inflammatory Status in Hemodialysis Patients

Myostatin (MSTN) is a negative regulator of skeletal muscle growth. However, previous studies in hemodialysis patients have reported inconsistent associations between circulating MSTN and muscle-related parameters, and the reasons for these discrepancies remain unclear. This cros...

TBK1 eliminates aggregation-prone monomeric TDP-43 through an IFNβ-immunoproteasome pathway in ALS models

Abstract Loss-of-function mutations in TANK-binding kinase 1 (TBK1) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), characterized by cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP-43), known as TDP-43 pathology, but the mechanisms beyond i...

Efficacy of Tympanic Membrane Regeneration Therapy for Secondary Cholesteatoma With Tympanic Membrane Perforation

OBJECTIVE: To investigate the effectiveness of tympanic membrane (TM) regeneration therapy (TMRT) for secondary cholesteatoma (SC) with TM perforation (TMP). STUDY DESIGN: Retrospective case review. SETTING: General hospitals. PATIENTS: The study included 38 patients (41 ears) wi...

Tailoring electrolyte salt concentration to achieve reversible Li storage in pure-Ni layered oxide

Abstract Modulating electrolyte formulation is an efficient strategy to mitigate side reactions at the electrode/electrolyte interface and thereby enhance the cycling stability of lithium batteries. Herein, the effects of electrolyte salt concentration on the solution structure a...

Association Between Texture-Modified Diet Intake Rate and Functional Outcomes After Acute Stroke: A Retrospective Observational Study

Background/Objectives: Texture-modified diets (TMDs) are commonly prescribed after stroke, but the clinical significance of the amount actually consumed remains unclear. We examined the association between TMD intake rate and functional status at discharge and 90 days after strok...

Smoking status and adherence to diagnostic follow-up after community-based low-dose CT screening

Background Low-dose computed tomography (CT) screening reduces lung cancer–specific mortality; however, its effectiveness depends on adherence to recommended diagnostic follow-up after abnormal findings. Factors associated with follow-up nonattendance in real-world screening sett...

Screening Lithium-Ion Conductors Based on Local and Global Topology

Abstract The discovery of high-performance solid-state electrolytes remains a critical challenge for all-solid-state Li-ion batteries. To accelerate the identification of novel Li-ion conductors, we developed a hierarchical screening framework combining local structure order para...

Mechanosensitive Stanniocalcin-1 Suppresses Pulmonary Artery Smooth Muscle Cell Proliferation and Attenuates Experimental Pulmonary Hypertension

BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is driven by progressive vascular remodeling, particularly smooth muscle cell (SMC) proliferation. Current combination vasodilator therapies have markedly improved outcomes; however, prognosis remains poor in subgroups...