Shiga University of Medical Science

Intertwined bulk photocarrier and interfacial barrier dynamics in van der Waals point-contact Schottky junctions

Abstract Schottky junctions based on transition-metal dichalcogenides underpin next-generation optoelectronic devices, yet the nanoscale carrier dynamics that ultimately govern their performance remain largely inaccessible. Here, we employ optical pump–probe time-resolved atomic...

Regional effect of population-based programs promoting salt reduction and potassium intake in Hokkaido: a post hoc analysis of the PoSPIP

Abstract The Population-based Sodium/Potassium Improvement Program is a nonrandomized population-based intervention implemented by the Japanese Society of Hypertension across multiple municipalities and workplaces in Japan. This post hoc regional analysis focused on two municipal...

Biophysical and structural characterisation of a quasi-stable toxic dimer of amyloid Aβ42 peptide tethered at position 34

Abstract Non-fibrillar oligomeric forms of amyloid β (Aβ) mediate toxicity in Alzheimer’s disease (AD) with Aβ accumulation preceding tau aggregation and synaptic damage. Aβ oligomerization is thought to initiate from the smallest stable unit, the dimer, yet structural details of...

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a conventional observational and two‐sample Mendelian randomization (MR) study in the same population (triangulation). We followed 13,695 individuals aged 35–69 years for cancer...

Single‐Cell RNA Sequencing‐Based Identification of Novel Podocyte Injury‐Associated Genes From Isolated Glomeruli of Diabetic db/db Mice

ABSTRACT Podocyte injury is a primary driver of progression in diabetic kidney disease (DKD). Although single‐cell RNA sequencing (scRNA‐seq) is a powerful tool for identifying novel disease‐associated genes, podocytes are frequently underrepresented in whole‐kidney scRNA‐seq dat...

Association between place of death and regional variation in senility mortality in Japan: a nationwide ecological study

Abstract Background In recent years, senility mortality has increased substantially in Japan, accounting for 12.9% of all deaths in 2024. Although senility (International Classification of Diseases, Tenth Revision, code R54) is often regarded as a non-specific cause of death in i...

Bilateral periorbital subcutaneous emphysema following Le Fort I osteotomy: a case report

Subcutaneous emphysema is a rare but recognised complication of orthognathic surgery. When it extends to the periorbital region after a Le Fort I osteotomy (LFI), the eyelid swelling can be alarming for the patient and may delay early functional recovery. Periorbital extension an...

Advanced machine learning techniques for daily streamflow forecasting: a case study of the Brahmaputra River

Accurate multi-day streamflow forecasts support flood preparedness, but single holdout scores can conceal lead-time dependence, temporal instability, baseline skill, and uncertainty. This study compares Long Short-Term Memory, Random Forest, Multiple Linear Regression, Multi-Laye...

Comparable outcomes with reoperative versus primary total arch replacement

Abstract Purpose Resternotomy during total arch replacement surgery is associated with adverse outcomes. We aimed to determine the accuracy of this statement. Methods From January 2008 to February 2021, 384 consecutive total arch replacement surgeries were performed at our instit...

Acute limb ischemia revealing AL cardiac amyloidosis despite sustained sinus rhythm: a case report

Abstract Background Thromboembolic complications are well recognized in cardiac amyloidosis and are traditionally attributed to atrial fibrillation (AF). However, patients with immunoglobulin light-chain (AL) cardiac amyloidosis remain at substantial thromboembolic risk, even in...

Emergency care competencies for non–emergency medicine specialists in Japan: a modified Delphi study

Abstract Background Physicians from specialties other than emergency medicine (non-EM specialists) provide first-contact emergency care in many health systems. Existing emergency care courses and competency frameworks address resource-limited first-contact care or rural self-suff...